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OncoImmunology Volume 10, 2021 - Issue 1
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The dark side of ferroptosis in pancreatic cancer

Jiao Liua Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
,
Enyong Daib Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China
,
Rui Kangc Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
,
Guido Kroemerd INSERM U1138, Centre de Recherche des Cordeliers, Equipe Labellisée Par la Ligue Contre lCancer, Université de Paris, Sorbonne Université, Paris, France;e Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France;f Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France;g Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China;h Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, SwedenORCID Iconhttps://orcid.org/0000-0002-9334-4405
ORCID Icon &
Daolin Tanga Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China;c Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1903-6180
ORCID Icon
Article: 1868691 | Received 15 Dec 2020, Accepted 21 Dec 2020, Published online: 04 Jan 2021

Figures & data

Figure 1. Ferroptotic damage promotes Kras-driven pancreatic tumorigenesis by macrophage polarization. The induction of ferroptotic damage by high-iron diets or Gpx4 depletion in pancreatic acinar cells promotes the release of nuclear DNA containing 8-hydroxy-2ʹ-deoxyguanosine (8-OHG) into the cytosol and thus activates the STING1-dependent DNA sensor pathway, resulting in macrophage infiltration and polarization during Kras-driven PDAC in mice

Figure 1. Ferroptotic damage promotes Kras-driven pancreatic tumorigenesis by macrophage polarization. The induction of ferroptotic damage by high-iron diets or Gpx4 depletion in pancreatic acinar cells promotes the release of nuclear DNA containing 8-hydroxy-2ʹ-deoxyguanosine (8-OHG) into the cytosol and thus activates the STING1-dependent DNA sensor pathway, resulting in macrophage infiltration and polarization during Kras-driven PDAC in mice

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