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OncoImmunology Volume 10, 2021 - Issue 1
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CDK1/2/5 blockade: killing two birds with one stone

Jiao Liua Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
,
Rui Kangb Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
&
Daolin Tanga Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China;b Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1903-6180
ORCID Icon
Article: 1875612 | Received 06 Jan 2021, Accepted 08 Jan 2021, Published online: 20 Jan 2021

Figures & data

Figure 1. The strategy of boosting antitumor immune activity in PDAC by inhibiting CDK1/2/5. Inhibiting CDK1/2/5 by dinaciclib not only blocks IFNG-induced immune checkpoint expression, but also triggers histone-dependent immunogenic cell death

Figure 1. The strategy of boosting antitumor immune activity in PDAC by inhibiting CDK1/2/5. Inhibiting CDK1/2/5 by dinaciclib not only blocks IFNG-induced immune checkpoint expression, but also triggers histone-dependent immunogenic cell death

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