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OncoImmunology Volume 11, 2022 - Issue 1
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Editorial

Beneficial autoimmunity and maladaptive inflammation shape epidemiological links between cancer and immune-inflammatory diseases

Jonathan Pola Equipe 11 Labellisée Par La Ligue Nationale Contre Le Cancer, Centre de Recherche Des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Paris, France;b Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, FranceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8355-7562View further author information
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Juliette Pailleta Equipe 11 Labellisée Par La Ligue Nationale Contre Le Cancer, Centre de Recherche Des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Paris, France;b Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, FranceORCID Iconhttps://orcid.org/0000-0001-7118-7165View further author information
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Céleste Plantureuxa Equipe 11 Labellisée Par La Ligue Nationale Contre Le Cancer, Centre de Recherche Des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Paris, France;b Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France;c Université Paris-Saclay, Faculté de Médecine, Kremlin-Bicêtre, FranceORCID Iconhttps://orcid.org/0000-0003-4437-0479View further author information
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Guido Kroemera Equipe 11 Labellisée Par La Ligue Nationale Contre Le Cancer, Centre de Recherche Des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Paris, France;b Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France;d Institut Universitaire de France, Paris, France;e Pôle de Biologie, Hôpital Européen Georges Pompidou, Ap-hp, Paris, France;f Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China;g Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, SwedenCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9334-4405View further author information
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Article: 2029299 | Received 30 Dec 2021, Accepted 11 Jan 2022, Published online: 18 Jan 2022

Figures & data

Figure 1. Epidemiological links between systemic autoimmune diseases and breast cancer. (a). Repeated acute inflammatory responses and autoimmune damage can cause chronic inflammation and promote carcinogenesis. By contrast, some autoimmune diseases have been associated with a reduced incidence or progression of cancer, as these pathologies can fuel the immunosurveillance of (pre)malignant cells. (b). Several studies have revealed a negative association between breast cancer and some autoimmune manifestations such as rheumatoid arthritis, systemic lupus erythematosus, and psoriatic or enteropathic arthropathies.

Figure 1. Epidemiological links between systemic autoimmune diseases and breast cancer. (a). Repeated acute inflammatory responses and autoimmune damage can cause chronic inflammation and promote carcinogenesis. By contrast, some autoimmune diseases have been associated with a reduced incidence or progression of cancer, as these pathologies can fuel the immunosurveillance of (pre)malignant cells. (b). Several studies have revealed a negative association between breast cancer and some autoimmune manifestations such as rheumatoid arthritis, systemic lupus erythematosus, and psoriatic or enteropathic arthropathies.

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