COMT and 5-HT1A-receptor genotypes potentially affect executive functions improvement after cognitive remediation in schizophrenia

Figures & data

Table 1. Demographic, clinical and neuropsychological features of the sample, stratified by COMT and 5-HT1A-R genotypes.

COMT rs4680	Val/Val	Val/Val	Met carriers	Met carriers	ANOVA/
5-HT1A-R rs6295	G/G	C carriers	G/G	C carriers	Chi-squared
	(Mean ± SD)	(Mean ± SD)	(Mean ± SD)	(Mean ± SD)
Gender	M = 4; F = 4	M = 7; F = 6	M = 12; F = 5	M = 30; F = 18	N.S.
Age (yrs)	31.67 ± 4.05	36.53 ± 2.56	34.29 ± 2.41	33.62 ± 1.40	N.S.
Education (yrs)	12.5 ± 0.93	11.54 ± 2.18	10.76 ± 2.93	11.98 ± 3.04	N.S.
Onset (yrs)	22.12 ± 4.45	27.85 ± 11.46	24.53 ± 6.46	23.13 ± 5.36	N.S.
Duration of illness (yrs)	6.63 ± 5.10	11.15 ± 7.84	12.41 ± 7.33	9.73 ± 8.25	N.S.
PANSS negative (score)	20.49 ± 2.23	19.55 ± 4.53	19.29 ± 5.35	19.76 ± 5.40	N.S.
PANSS positive (score)	13.22 ± 0.90	13.48 ± 2.41	12.75 ± 2.49	13.88 ± 3.46	N.S.
PANSS general (score)	33.60 ± 2.99	32.24 ± 4.92	32.22 ± 4.71	32.54 ± 5.01	N.S.
PANSS total (score)	67.29 ± 4.33	65.28 ± 11.13	64.26 ± 9.56	66.18 ± 10.89	N.S.
Total I.Q.	85.63 ± 11.29	86.89 ± 9.58	84.45 ± 12.91	86.44 ± 13.07	N.S.
WCST pers. errors	23.87 ± 12.29	15.00 ± 8.14	15.41 ± 9.91	16.69 ± 11.08	N.S.(Ancova)

Note: yrs, years; SD, standard deviation; N.S., not significant; M, males; F, females.

Figure 1. Mean effect size of improvement in executive functions, evaluated by means of WCST number of perseverative errors, stratified by COMT and 5-HT1A-R genotypes.