Decline in rotavirus hospitalizations following the first three years of vaccination in Castile-La Mancha, Spain

Figures & data

Figure 1. Counting of hospital admissions by IAGE of typified and non-typified etiology. Source: MBDS. CLM, Spain. 2003–09.*

Table 1. Hospital admissions for rotavirus (per 10⁵) compared to overall admissions for infectious AGE and admissions for non-typified AGE for the three-year periods 2003-05 and 2007-09. Source: MBDS. Castile-La Mancha, Spain*

2003–05 Age	Overall infectious AGE^a		AGE for rotavirus				Non-typified AGE^b
	N	Median rate	N	Median rate	% rota/overall AGE by group	% rota by group/total rota	N	Median rate
0–6 ms	316	780.5	189	403.1	59.8	24.6	420	1037.3
7–11 ms	276	939.9	212	701.6	76.8	27.6	370	1260.0
< 1 y	592	847.5	401	529.5	67.7	52.2	790	1131.1
1 y	370	695.8	246	393.0	66.5	32.0	615	1156.6
2 y	177	330.0	78	145.3	44.1	10.1	307	572.5
3 y	74	136.3	19	38.5	25.7	2.47	212	390.7
4 y	69	126.8	14	16.5	20.3	1.8	141	259.2
< 5 y	1282	594.8	758	224.7	59.1	98.6	2065	958.4
≥ 5 y	1093	21.0	11	1.1	1.01	1.4	3209	61.7
Total	2375	43.9	769	11.3	32.4	100.0	5274	97.3
2007–09	Overall infectious AGE^a		AGE for rotavirus				Non-typified AGE^b
Age	N	Median rate	N	Median rate	% rota/overall AGE by group	% rota by group/total rota	N	Median rate
0–6 ms	248	642.0	154	356.8	62.1	23.3	387	1001.8
7–11 ms	224	811.5	163	469.5	72.8	24.6	331	1199.1
< 1 y	472	712.6	317	403.7	67.2	47.9	718	1084.1
1 y	323	534.8	231	343.2	71.5	34.9	528	874.0
2 y	115	194.1	63	92.1	54.8	9.5	264	445.4
3 y	60	102.3	24	35.6	40.0	3.6	153	260.8
4 y	46	78.7	13	19.8	28.3	2.0	118	201.9
< 5 y	1016	429.1	648	184.5	63.8	97.9	1781	752.4
≥ 5 y	864	15.3	14	1.1	1.6	2.1	3594	63.7
Total	1880	32.0	662	9.7	35.2	100.0	5375	91.5

*AGE: acute gastroenteritis; MBDS: Minimum Basic Data Set. Rota: rotavirus; ms: months; y: years old.

^aPrincipal diagnosis of bacterial or parasitic AGE (001–005, 006–007, and 008.0–008.5) and viral AGE (008.6 to 008.8), excluding a principal diagnosis of localized salmonella infection (003.21–003.24) or amebic abscess (006.3–006.6). Also, non-typified AGE with a secondary diagnosis of infectious (typified) AGE.

^bNon-typified AGE without a secondary diagnosis of infectious AGE: “AGE of undetermined cause” (009.0 to 009.3), “unspecified noninfectious AGE” (558.9), or “diarrhea” (787.91).

Figure 2. Distribution of triennial rates of acute rotavirus gastroenteritis by provinces. Children under 5 y of age. MBDS. CLM, Spain. 2003–05 and 2007–09. MBDS: Minimum Basic Data Set. CLM: Castile-La Mancha.

Figure 3. Seasonal distribution of the number of hospitalizations caused by rotavirus, Salmonella spp., Campylobacter jejuni and non-typified AGE. Children under 5 y of age. MBDS. CLM, Spain. 2003–09. AGE: acute gastroenteritis. MBDS: Minimum Basic Data Set. CLM: Castile-La Mancha.

Figure 4. Distribution of incidence rates of rotavirus hospital discharges by year groups. Children under 5 y of age. MBDS. CLM, Spain. 2003–09. MBDS: Minimum Basic Data Set. CLM: Castile-La Mancha. Y: year/s.

Figure 5. Distribution of rotavirus hospital discharge rates by year. Children under 5 y of age. MBDS. CLM, Spain. 2003–09. MBDS: Minimum Basic Data Set. CLM: Castile-La Mancha.

Table 2. Multivariate analysis: comparison of the incidence rates of rotavirus hospital discharges in CLM in the triennium 2007–09 vs. the triennium 2003-05. Source: MBDS. Castile-La Mancha, Spain*

Variables	IRR	CI 95%	P value
2007–09 vs. 2003–05 trienniums	0.86	0.78–0.96	0.006
Age
< 1 y	0.90	0.77–1.03	0.148
1 y	0.87	0.62–1.20	0.395
2 y	0.42	0.23–0.79	0.007
3-4 y	0.72	0.33–1.55	0.399
5-9 y	1.77	0.61–5.07	0.291
≥ 10 y	3.87	0.64–23.47	0.141
Sex
Male	0.85	0.64–0.98	0.023
Female	0.88	0.75–1.03	0.121
Provinces
Toledo	0.54	0.39–0.75	0.001
Ciudad Real	0.89	0.77–1.04	0.146
Guadalajara	0.87	0.71–1.08	0.218
Albacete	0.78	0.57–1.07	0.118
Cuenca	1.32	0.93–1.89	0.124

*Poisson regression, adjusted for age, sex, and province.

MBDS: Minimum Basic Data Set.

IRR: Incidence Rate Ratio.

Y: years old.