A longitudinal study of streptococcus pneumoniae carriage in healthy children in the 13-valent pneumococcal conjugate vaccine era

Figures & data

Table 1. Main characteristics of the study children

	T0N (%)	T6N (%)	T12N (%)
Age (months)
3–12	442 (71.5)	371(72.0)	317 (72.7)
13–24	153 (24.8)	123(23.9)	101 (23.2)
25–59	23(3.7)	21 (4.1)	18 (4.1)
Total	618 (100.0)	515(100.09	436 (100.0)
Gender
Female	278 (45.0)	239(46.4)	207(47.5)
Male	340 (55.0)	276 (53.6)	229 (52.5)
Total	618 (100)	515 (100.0)	436 (100.0)
Ethnic group
Non-Caucasian	105 (17.0)	81(15.7)	56(12.8)
Caucasian	513 (83.0)	434 (84.3)	380(87.2)
Total	618 (100.0)	515 (100.0)	436 (100.0)
Upper and lower respiratory infection in the previous 90 days
No	373 (60.4)	144 (28.0)	177 (40.6)
Yes	245 (39.6)	371 (72.0)	259 (59.4)
Total	618 (100.0)	515 (100.0)	436 (100.0)
Antibiotics in the previous 90 days
No	510 (82.5)	321 (62.3)	346 (79.4)
Yes	108 (17.5)	194 (37.7)	90 (20.6)
Total	618 (100.0)	515 (100.0)	436 (100.0)
Antibiotics in the previous 7 days
No	585 (94.7)	474 (92.0)	409 (93.8)
Yes	33 (5.3)	41 (8.0)	27 (6.2)
Total	618 (100.0)	515 (100.0)	436 (100.0)
PCV13 uptake by age
PCV13-incompletely vaccinated for age	447 (72.3)	169 (32.8)	35 (8.0)
PCV13-appropriately vaccinated for age	171 (27.7)	346 (67.2)	401 (92.0)
Total	618 (100.0)	515 (100.0)	436 (100.0)
SP carriage
No	467 (75.6)	373 (72.4)	312 (71.6)
Yes	151 (24.4)	142 (27.6)	124 (28.4)
Total	618 (100.0)	515 (100.0)	436 (100.0)

Table 2. Frequency of Streptococcus pneumoniae serotype isolation

	Baseline		T6		T12		Total
	N	%	N	%	N	%	N	%
PCV13 serotypes
3	0	0.0	4	2.8	2	1.6	6	1.4
6A	4	2.6	3	2.1	2	1.6	9	2.2
6B	1	0.7	0	0.0	0	0.0	1	0.2
9V	1	0.7	0	0.0	0	0.0	1	0.2
14	2	1.3	2	1.4	2	1.6	6	1.4
19A	6	4.0	0	0.0	2	1.6	8	1.9
19F	8	5.3	2	1.4	0	0.0	10	2.4
23F	2	1.3	2	1.4	0	0.0	4	1.0
Non-PCV13 serotypes
6C	12	7.9	8	5.6	9	7.3	29	7.0
7A	2	1.3	0	0.0	0	0.0	2	0.5
8	0	0.0	0	0.0	1	0.8	1	0.2
9L	1	0.7	0	0.0	0	0.0	1	0.2
10A	7	4.6	4	2.8	10	8.1	21	5.0
11A	8	5.3	17	12.0	14	11.3	39	9.4
11C	1	0.7	1	0.7	0	0.0	2	0.5
11F	0	0.0	1	0.7	0	0.0	1	0.2
12A	0	0.0	0	0.0	1	0.8	1	0.2
12B	0	0.0	0	0.0	1	0.8	1	0.2
12F	0	0.0	0	0.0	2	1.6	2	0.5
13	0	0.0	2	1.4	0	0.0	2	0.5
15A	6	4.0	12	8.5	29	23.4	47	11.3
15B	7	4.6	15	10.6	0	0.0	22	5.3
15C	2	1.3	3	2.1	0	0.0	5	1.2
15F	2	1.3	2	1.4	0	0.0	4	1.0
16A	3	2.0	6	4.2	3	2.4	12	2.9
16F	1	0.7	1	0.7	1	0.8	3	0.7
17F	0	0.0	1	0.7	1	0.8	2	0.5
21	2	1.3	5	3.5	4	3.2	11	2.6
22F	3	2.0	0	0.0	4	3.2	7	1.7
23A	13	8.6	12	8.5	7	5.6	32	7.7
23B	8	5.3	8	5.6	3	2.4	19	4.6
24A	1	0.7	6	4.2	1	0.8	8	1.9
24F	1	0.7	2	1.4	4	3.2	7	1.7
25	1	0.7	0	0.0	0	0.0	1	0.2
28F	0	0.0	0	0.0	3	2.4	3	0.7
29	6	4.0	2	1.4	4	3.2	12	2.9
31	2	1.3	0	0.0	1	0.8	3	0.7
33	2	1.3	1	0.7	2	1.6	5	1.2
34	3	2.0	4	2.8	0	0.0	7	1.7
35F	10	6.6	4	2.8	9	7.3	23	5.5
38	2	1.3	2	1.4	0	0.0	4	1.0
39	2	1.3	0	0.0	0	0.0	2	0.5
NT	19	12.6	10	7.0	1	0.8	30	7.2
UNK	0	0.0	0	0.0	1	0.8	1	0.2
Total	151	100.0	142	100.0	124	100.0	417	100.0

Abbreviations: N: number: UNK: unknown serotypes (nasopharyngeal isolates identified as S. pneumoniae died during the passage on plate).

Figure 1. Frequency of Streptococcus pneumoniae carriage during the study. See Table 2 for the corresponding raw numbers. UNK: unknown serotypes (nasopharyngeal isolates identified as S. pneumoniae, died during the passage on plate).