Pancreatic cancer, treatment options, and GI-4000

Figures & data

Figure 1. GI-4000 Series: Four different strains: GI-4014, -4015, -4016, -4020 of heat-inactivated S. Cerevisiae; each express a mutated Ras fusion protein. The mutations of RAS represent the most common mutations found in solid tumors via genotype analysis.Each strain bares a fusion protein that is inclusive of 3 different RAS mutation combinations; 2 of the mutations are found on codon 61 and the other on codon 12. (http://meetinglibrary.asco.org/content/40075?format=posterImg) – Permission required.

Figure 2. Overall Survival (OS) of patients with a G12R mutation compared with all other Ras mutations, regardless of treatment.³⁴

Coeshott C, Holmes T, Mattson A, Bellgrau D, King T, Guo Z, Roder H, Roder J, Cohn A, Rodell TC. Immune Responses To Mutated Ras - Development Of A Yeast Based Immunotherapeutic. In: AACR-RAS Oncogene Conference 2014.

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