Effectiveness of prevention of mother-to-child transmission practice in three provinces of Southern China

Figures & data

Figure 1. Subject enrollment in the study in south China, 2011.

Table 1. Characteristics of the study population in 3 provinces of Southern China, 2011

	Guangxi (N = 524)		Hunan (N = 773)		Yunnan (N = 1797)		Total (N = 3120)
Category	n	%	n	%	N	%	n	%
Age of mother (years)
<25	183	34.9	345	44.6	877	48.8	1405	45.4
25∼	174	33.2	278	36.0	544	30.3	996	32.2
≥30	167	31.9	150	19.4	376	20.9	693	22.4
Hospital level
Prefectural or above	90	17.2	112	14.5	260	14.5	462	14.9
County	280	53.4	397	51.4	1207	67.2	1884	60.9
Township	154	29.4	264	34.1	330	18.3	748	24.2
Gender of infant
Male	280	53.4	444	57.4	961	53.5	1685	54.5
Female	244	46.6	329	42.6	836	46.5	1409	45.6
Age of infant (months)
7	81	15.5	80	10.3	373	20.8	534	17.3
8	134	25.6	112	14.5	598	33.3	844	27.3
9	102	19.5	173	22.4	481	26.8	756	24.4
10	106	20.2	202	26.1	181	10.1	489	15.8
11	101	19.3	206	26.7	164	9.1	471	15.2
HBeAg status of mother
Negative	331	63.2	524	67.8	1059	58.9	1914	61.9
Positive	193	36.8	249	32.2	738	41.1	1180	38.1

Table 2. Univariate Analysis of HBsAg Prevalence among Infants in 3 provinces of Southern China, 2011

		HBsAg Positive Infants
Variables	N	n	%	Statistical Tests
Age of mother (years)
<25	1405	82	5.8	χ^2 = 1.15, P = 0.563
25∼	996	49	4.9
≥30	693	41	5.9
Hospital level
Prefectural or above	462	17	3.7	χ^2 = 3.65, P = 0.16
County	1884	111	5.9
Township	748	44	5.8
HBeAg status of mother
Negative	1914	73	3.8	χ^2 = 29.11, P < 0.001
Positive	1180	99	8.4
Mother received HBIG during pregnancy
Yes	309	13	4.2	χ^2 = 1.71, P = 0, 425
No	2531	147	5.8
Unknown	254	12	4.7
Gender of infant
Male	1685	96	5.7	χ^2 = 0.14, P = 0.714
Female	1409	76	5.4
Age of infant (months)
7	534	19	3.6	χ^2 = 9.20, P = 0.056
8	844	48	5.7
9	756	37	4.9
10	489	33	6.7
11	471	35	7.4
Premature infant
Yes	144	11	7.6	χ^2 = 1.24, P = 0 .265
No	2950	161	5.5
Low birth weight infant
Yes	125	13	10.4	χ^2 = 5.81, P = 0 .016
No	2969	159	5.4
Feeding method
Breast fed	1882	115	6.1	χ^2 = 2.78, P = 0 .095
Bottle fed	1212	57	4.7
Hepatitis B vaccine dose
5 μg yeast vaccine	172	17	9.9	χ^2 = 6.54, P = 0 .038
10 μg yeast vaccine	2585	138	5.3
20 μg CHO vaccine	337	17	5.0
Vaccine and HBIG combination
Yes	2271	123	5.4	χ^2 = 0.33, P = 0 .564
No	823	49	5.9
TBD
Yes	2995	158	5.2	χ^2 = 14.35, P < 0.001
No	99	14	14.1
Total	3094	172	5.6

Table 3. Multiple Factor Logistic Regression Analysis on HBsAg Status of Infants in 3 provinces of Southern China, 2011

Variables	Category	Frequency	RR	RR 95%CI	P
HBeAg status of mother	Negative*	1914	1
	Positive	1180	2.26	1.65˜3.10	0.000
TBD	Yes*	2995	1.00
	No	99	2.87	1.52˜5.40	0.001
Vaccine dose	5 μg yeast vaccine*	172	1
	10 μg yeast vaccine	2585	0.52	0.31˜0.90	0.018
	20 μg CHO vaccine	337	0.47	0.23˜0.96	0.038
Age of infants (months)	7*	534	1
	8	844	1.58	0.91˜2.72	0.103
	9	756	1.42	0.80˜2.52	0.228
	10	489	2.00	1.11˜3.60	0.021
	11	471	2.20	1.23˜3.94	0.008
Vaccine and HBIG combination	Yes*	2271	1
	No	823	0.91	0.64˜1.30	0.601
Low birth weight infants	Yes*	125	1
	No	2969	0.66	0.35˜1.25	0.198