Intussusception following rotavirus vaccination in the Valencia Region, Spain

Figures & data

Figure 1. Intussusception-hospitalized rates by age in unvaccinated Valencia Region´s children aged less than 12 months during 2001–2011.

Figure 2. Flowchart of hospitalized-intussusception cases.

Table 1. Positive predictive values according to The Brighton Collaboration case classification by discharge code position, and by calendar year

		Positive Predictive Values
	Casesn	Level 1% (95% CI)	Level 1- Level 2% (95% CI)	Level 1-Level 2-Level 3 % (95% CI)
Discharge code position
1^st	148	86.5 (79.9–91.5)	93.2 (87.9–96.7)	94.6 (89.6–97.6)
1^st or 2^nd	149	86.6 (80.0–91.6)	93.3 (88.0–96.7)	94.6 (89.7–97.7)
Any	151	85.4 (78.8–90.6)	92.7 (87.3–96.3)	94.0 (89.0–97.2)
Calendar year
2007	44	81.8 (67.3–91.8)	90.9 (78.3–97.5)	95.5 (84.5–99.4)
2008	30	86.7 (69.3–96.2)	93.3 (77.9–99.2)	93.3 (77.9–99.2)
2009	25	84.0 (63.9–95.5)	92.0 (74.0–99.0)	92.0 (74.0–99.0)
2010	28	89.3 (71.8–97.7)	92.9 (76.5–99.1)	92.9 (76.5–99.1)
2011	24	87.5 (67.6–97.3)	95.8 (78.9–99.9)	95.8 (78.9–99.9)

¹ Any diagnosis position.

Abbreviations: Positive Predictive Value (PPV); Confidence interval (CI).

Table 2. Risk estimates for confirmed intussusception cases after Rotarix®/RotaTeq® vaccination, vaccinees-only SCCS approach

Vaccine dose	Risk period(days post-vaccination)	Number of cases	Non-risk period(days post-vaccination)	Number of cases	IRR (95% CI)(crude)	IRR (95% CI)(age-adjusted)
Dose 1
	1–7	3	22–42	1	9.0 (0.9–86.5)	4.7 (0.3–74.1)
	8–21	1			1.5 (0.1–24.0)	0.8 (0.1–13.9)
Dose 2
	1–7	1	22–42	2	1.5 (0.1–16.5)	1.6 (0.1–32.3)
	8–21	3			2.3 (0.4–13.5)	3.9 (0.3–44.0)
Dose 3
	1–7	0	22–42	1	3.0 (0.2–48.0)	Non interpretable
	8–21	0			Non interpretable	Non interpretable

* The observation period for each vaccine dose ends at day 42 post-vaccination.

¹ Non-interpretable IRR due to very small numbers.

Abbreviations: Intussusception (IS); Confidence interval (CI).