Optimal vaccination program for healthy adults in China

Figures & data

Figure 1. Participant disposition (Group A: 0-1-3 schedule, group B: 0-1-6 schedule, group C: 0-1-12 schedule; *: To analysis the immunogenicity effect of hepatitis B vaccine, subjects with positive anti-HBc antibody who also got full vaccination was deleted in the process of analysis.).

Table 1. Gender and age distribution of participants after 12 months follow-up

	Gender^a			Age
Vaccination program	Male (%)	Female	P	15˜	25˜	35˜	45˜	mean (SD )	P
0-1-3	354(40.5)	519	0.309	168	376	259	70	32.75(7.93)	0.140
0-1-6	338(39.3)	523		144	333	314	70	33.31(7.71)
0-1-12	259(36.8)	445		126	288	233	57	33.16(8.00)
total	951(39.0)	1487		438	997	806	197	33.07(7.87)

^aOne missing in gender group.

Table 2. Summary of seroconversion rate and GMT by different variables

	Seroprotection rate (%)/ 95%CI			GMT(mIU/mL)/ 95%CI
Variables	1 month	12 month	P	1 month	12 month	P
Schedule
0-1-3	100	65.0(61.8,68.1)	0.0001	213.16(189.93,239.23)	22.07(19.19,25.37)	0.002
0-1-6	99.9(99.7,100)	75.7(72.9,78.6)	0.0006	432.58(382.91,488.69)	46.70(39.69,54.94)	0.0002
0-1-12	97.9(96.8,98.9)	79.0(76.0,82.0)	0.0002	451.47(383.92,530.92)	56.18(45.68,69.11)	0.0006
Total	99.3(99.0,99.7)	72.8(71.0,74.6)	0.0009	339.91(314.72,367.12)	37.66(34.15,41.54)	0.0003
P	0.0006	0.0002		0.0004	0.0003
Gender
male	99.2(98.6,99.7)	71.3(68.4,74.2)	0.001	294.56(259.01,334.99)	34.29(29.20,40.25)	0.0004
Female	99.5(99.1,99.8)	73.8(71.5,76.0)	0.0005	372.52(338.56,409.88)	39.99(35.34,45.25)	0.0004
P	0.366	0.180		0.004	0.133
age
15˜	98.9(97.9,99.9)	80.1(76.4,83.9)	0.0002	402.08(330.13,489.70)	58.48(47.64,71.78)	0.0005
25˜	99.4(98.9,99.9)	73.3(70.6,76.1)	0.0002	362.43(321.99,407.95)	40.27(34.61,46.85)	0.0001
35˜	99.5(99.0,100)	69.1(65.9,72.3)	0.0004	306.30(268.50,349.42)	30.15(25.33,35.88)	0.0001
45˜	99.5(98.5,100)	69.0(62.5,75.6)	0.0001	258.96(200.00,335.29)	25.09(16.88,37.29)	0.0003
P	0.570	0.0003		0.014	0.0007

GMT: geometric mean titer, 95%CI: 95% confidence interval

Table 3. High-response rate among groups A–C

		High-response rate /95%CI(%)
Vaccination program	N	1 month	12 month
0-1-3	873	64.4(61.2,67.6)	22.0(19.2,24.8)
0-1-6	861	74.6(71.7,77.5)	39.7(36.5,43.0)
0-1-12	704	76.8(73.7,80.0)	44.2(40.5,47.9)
Total	2438	71.6(69.8,73.4)	34.7(32.8,36.6)
P		0.0002	0.0002

Table 4. Correlation between GMTs and the age groups using bivariate correlations

	GMT(mIU/mL)/ 95%CI
Age	1 month	12 month
15˜	402.08(330.13,489.70)	58.48(47.64,71.78)
25˜	362.43(321.99,407.95)	40.27(34.61,46.85)
35˜	306.30(268.50,349.42)	30.15(25.33,35.88)
45˜	258.96(200.00,335.29)	25.09(16.88,37.29)
r	−0.072	−0.105
P	0.0004	0.0002