Effects of Fuzheng Paidu tablet on peripheral blood T lymphocytes, intestinal mucosa T lymphocytes, and immune organs in cyclophosphamide-induced immunosuppressed mice

Figures & data

Table 1. Effects of Fuzheng Paidu Tablet on the peripheral blood CD3+, CD4+, CD8+, and CD4+/CD8+ levels in CY-induced immunosuppressed mice

Group	Number of animals	CD3+	CD4+	CD8+	CD4+/ CD8+
Blank control	10	67.80 ± 8.52	44.77 ± 4.76	14.83 ± 1.73	3.05 ± 0.39
Model group	10	43.53 ± 5.87	33.43 ± 2.13	14.23 ± 1.26	2.36 ± 0.14
Lentinan group	10	63.92 ± 7.02	43.70 ± 2.55	15.41 ± 1.92	2.87 ± 0.37
Fuzheng Paidu: high dose group	10	73.07 ± 3.35	45.10 ± 3.25	14.86 ± 0.75	2.97 ± 0.21
Fuzheng Paidu: middle dose group	10	73.10 ± 10.61	44.48 ± 3.03	14.92 ± 1.31	2.99 ± 0.12
Fuzheng Paidu: low dose group	10	71.13 ± 9.22	41.67 ± 2.42	14.38 ± 1.07	2.90 ± 0.11

** Compared to the model group, P < 0.01.

Figure 1. Effects of Fuzheng Paidu Tablet on the intestinal CD3+ cells in CY-induced immunosuppressed mice.

Figure 2. Effects of Fuzheng Paidu Tablet on the intestinal CD4+ cells in CY-induced immunosuppressed mice.

Figure 3. Effects of Fuzheng Paidu Tablet on the intestinal CD8+ cells in CY-induced immunosuppressed mice.

Table 2. Effects of Fuzheng Paidu Tablet on the intestine mucosa T cells in CY-induced immunosuppressed mice

Group	Number of animals	CD3+	CD4+	CD8+
Blank control	10	21.63 ± 2.46	12.31 ± 1.22	18.64 ± 1.25
Model group	10	3.12 ± 0.67	0.06 ± 0.02	2.35 ± 0.03
Lentinan group	10	23.80 ± 1.25	20.47 ± 1.06	20.12 ± 0.86
Fuzheng Paidu: high dose group	10	22.45 ± 1.05	20.86 ± 1.12	22.40 ± 1.28
Fuzheng Paidu: middle dose group	10	9.27 ± 1.12	9.45 ± 0.73	8.10 ± 0.72
Fuzheng Paidu: low dose group	10	4.20 ± 0.46	4.25 ± 0.32	3.28 ± 0.26

** Compared to the model group, P < 0.01.

Table 3. Effects of Fuzheng Paidu Tablet on the splenic lymphoid nodule size and lymphocyte number in the spleen of CY-induced immunosuppressed mice

Group	Number of animals	Splenic lymphoid nodule(nm)	Number of lymphocytes	Thymus thickness(nm)	Number of lymphocytes
Blank control	10	14.26 ± 2.13	28.45 ± 5.24	21.36 ± 3.08	28.31 ± 2.67
Model group	10	4.64 ± 1.06	8.23 ± 2.17	8.45 ± 2.10	10.45 ± 2.02
Lentinan group	10	9.38 ± 1.32	16.37 ± 2.19	22.24 ± 3.12	31.23 ± 2.13
Fuzheng Paidu high: dose group	10	11.16 ± 2.08	18.76 ± 2.65	23.05 ± 2.27	28.06 ± 2.36
Fuzheng Paidu: middle dose group	10	8.04 ± 1.51	12.34 ± 1.09	22.16 ± 3.45	25.62 ± 2.24
Fuzheng Paidu: low dose group	10	4.72 ± 1.05	8.06 ± 1.12	11.35 ± 2.31	16.21 ± 2.06

** Compared to the model group, P < 0.01.

Table 4. Effects of Fuzheng Paidu Tablet on the intestinal mucosal pathology in CY-induced immunosuppressed mice

Group	Number of animals	−	+	++	+++
Blank control	10	10	0	0	0
Model group	10	0	0	1	9
Lentinan group	10	2	8	0	0
Fuzheng Paidu: high dose group	10	8	2	0	0
Fuzheng Paidu: middle dose group	10	2	8	0	0
Fuzheng Paidu: low dose group	10	0	1	2	7