Pneumococcal nasopharyngeal carriage in children <5  years of age visiting the pediatric emergency room in relation to PCV7 and PCV13 introduction in southern Israel

Figures & data

Figure 1. PCV7 and PCV13 vaccine uptake in southern Israel: proportion of children 12–23 months old with ≥2 PCV7 and PCV13 doses and proportion of children 24–35 months old with ≥3 PCV7 and PCV13doses.

Table 1. Pneumococcal carriage rates and odds ratios (ORs) in children < 5  y presenting to the pediatric emergency room, southern Israel - All children.

	VT7	6A	VT5	Non-13VT	Overall pneumococcal carriage
Nov 2009 – Jun 2010 (early PCV7)	16.80%	5.10%	8.10%	24.40%	54.30%
Jul 2010 – Jun 2011 (PCV7 impact)	9.60%	4.40%	8.50%	31.70%	54.20%
Jul 2011 – Jun 2012 (early PCV13, interim)	5.90%	2.00%	5.60%	35.70%	49.10%
Jul 2012 – Jun 2013 (early PCV13, interim)	4.60%	1.00%	3.90%	38.00%	47.50%
Jul 2013 – Jun 2014 (PCV13 impact)	4.00%	0.50%	2.80%	41.80%	49.10%
Jul 2014 – Dec 2014	3.40%	0.10%	2.10%	36.00%	41.60%
OR early PCV7 vs. PCV7 impact periods	0.57 (0.47–0.70)	0.86 (0.61–1.21)	1.05 (0.81–1.36)	1.30 (1.15–1.48)	0.99 (0.93–1.07)
OR PCV7 impact vs. PCV13 impact periods	0.42 (0.31–0.57)	0.12 (0.06–0.26)	0.33 (0.23–0.47)	1.32 (1.20–1.45)	0.91 (0.84–0.97)
OR early PCV7 vs. PCV13 impact periods	0.24 (0.18–0.32)	0.10 (0.05–0.23)	0.34 (0.24–0.50)	1.71 (1.51–1.94)	0.90 (0.84–0.98)
(Overall impact)

Figure 2. Pneumococcal carriage in children <5  years old attending pediatric emergency room, southern Israel, November 2009 through December 2014.

Table 2. Pneumococcal carriage rates and odds ratios (ORs) in children <12 , 12–23, 24–35, 36–59 months old  presenting to the pediatric emergency room, southern Israel - All children.

	<12m n = 3,579	12–23m n = 1, 955	24–35m n = 989	36–59m n = 1, 087
Nov 2009 – Jun 2010 (early PCV7)	54.40%	54.60%	54.10%	53.50%
Jul 2010 – Jun 2011 (PCV7 impact)	55.00%	56.00%	53.90%	47.70%
Jul 2011 – Jun 2012 (early PCV13, interim)	51.20%	48.00%	47.50%	45.80%
Jul 2012 – Jun 2013 (early PCV13, interim)	51.60%	50.80%	41.10%	49.90%
Jul 2013 – Jun 2014 (PCV13 impact)	46.10%	50.10%	49.90%	47.20%
Jul 2014 – Dec 2014	40.10%	48.10%	30.60%	43.20%
OR early PCV7 vs. PCV7 impact periods	1.01 (0.91–1.12)	1.03 (0.90–1.17)	1.00 (0.82–1.21)	0.89 (0.72–1.10)
OR PCV7 impact vs. PCV13 impact periods	0.84 (0.75–0.93)	0.90 (0.78–1.03)	0.93 (0.77–1.12)	0.99 (0.81–1.22)
OR early PCV7 vs. PCV13 impact periods (Overall impact)	0.85 (0.75–0.95)	0.92 (0.79–1.06)	0.92 (0.75–1.14)	0.89 (0.72–1.10)

Table 3. Pneumococcal carriage rates and odds ratios (ORs) in Jewish and Bedouin children <5  years old  presenting to the pediatric emergency room, southern Israel - All children.

	Jewish children n = 3, 110	Bedouin children n = 4, 500	p value
Nov 2009 – Jun 2010 (early PCV7)	45.70%	61.90%	<0.001
Jul 2010 – Jun 2011 (PCV7 impact)	46.00%	59.70%	<0.001
Jul 2011 – Jun 2012 (early PCV13, interim)	40.30%	54.20%	<0.001
Jul 2012 – Jun 2013 (early PCV13, interim)	41.60%	55.20%	<0.001
Jul 2013 – Jun 2014 (PCV13 impact)	42.10%	51.20%	0.002
Jul 2014 – Dec 2014	42.00%	41.60%	0.91
OR early PCV7 vs. PCV7 impact periods	1.01 (0.89–1.14)	0.96 (0.89–1.05)	ns
OR PCV7 impact vs. PCV13 impact periods	0.92 (0.80–1.04)	0.86 (0.79–0.93)	ns
OR early PCV7 vs. PCV13 impact periods (Overall impact)	0.92 (0.80–1.06)	0.83 (0.75–0.91)	ns

Figure 3. Pneumococcal carriage in children <5  years old attending pediatric emergency room, southern Israel: Jewish vs. Bedouin children.

Figure 4. Pneumococcal carriage in children 7–11, 12–23 and 24–59 months old attending pediatric emergency room, southern Israel: vaccinated vs. unvaccinated.