Impact of vaccination uptake on hospitalizations due to rotavirus acute gastroenteritis in 2 different socioeconomic areas of Spain

Figures & data

Figure 1. Rate of all causes AGE hospitalizations 2005–2013 (95% CI) Hospitalizations due to AGE (cases per 1,000 in children <2 y old population) in Hospital Torrecárdenas, Almería city and Hospital Poniente (El Ejido city) between 2005 and 2013. AGE, acute gastroenteritis. Annual rate of hospitalization was estimated using as denominator the number of newborns in birth cohorts during the present year and the previous year, and the obtained figure was divided by 2 CI: Confidence Interval.

Figure 2. Rate of Rotavirus hospitalizations 2005–2013 (95% CI) Hospitalizations due to Rotavirus (cases per 1,000 in children <2 y old population) in Hospital Torrecárdenas, Almería city and Hospital Poniente (El Ejido city) between 2005 and 2013. AGE, acute gastroenteritis. Annual rate of hospitalization was estimated using as denominator the number of newborns in birth cohorts during the present year and the previous year, and the obtained figure was divided by 2 CI: Confidence Interval.

Table 1. Changes in hospitalizations due to rotavirus AGE (2005–2013) and Coverage of rotavirus vaccine***

	Hospital in Almería city					Hospital in El Ejido
	AGE	Rotavirus	Incidence rate per 1,000 population^*	Change^**	Coverage of rotavirus vaccine	AGE	Rotavirus	Incidence rate per 1,000 population^*	Change^**	Coverage of rotavirus vaccine
Year	(n)	(n)		(%)	(%)	(n)	(n)		(%)	(%)
2005	97	32	4.50	—-	—-	45	12	2.71	—-	—-
2006	120	31	5.30	—-	—-	120	36	7.70	—-	—-
2007	114	42	7.20	↑ 35.80	77.1	71	18	3.80	↓ 40.80	23.7
2008	72	26	4.10	↓ 22.60	69.9	53	15	3.00	↓ 55.80	36.9
2009	50	10	1.60	↓ 69.80	66.1	53	13	2.50	↓ 55.80	44.8
2010	44	18	2.48	↓ 53.20	32.6	58	21	3.90	↓ 51.60	23.3
2011	44	15	2.11	↓ 60.20	50.5	63	25	4.60	↓ 47.50	25.3
2012	42	6	0.88	↓ 83.40	49.1	100	34	6.40	↓ 16.60	29.5
2013	51	17	2.60	↓ 50.90	48.2	101	29	5.40	↓ 15.80	42.6

Notes. AGE, acute gastroenteritis.

* Population of children <2 y old.

** Compared to year 2006.

**** % of patients with complete rotavirus vaccination (3 doses of RotaTeq® or 2 doses of Rotarix®

Table 2. Incidence Rate per 1000 in children < 2 y old population comparing pre-vaccine period (2005–2006) and After introduction period (2007–2013) in both Hospitals.

	Rotavirus Almería	Incidence rate per 1,000 population Almería		CI 95% shift
Year	(n)		Rate Ratio	Lower	Upper
2005–2006	63	4.86	1.67	1.24	2.25
2007–2013	134	2.90
	Rotavirus El Ejido	Incidence rate per 1,000 population El Ejido	Rate Ratio	CI 95% shift
Year	(n)			Lower	Upper
2005–2006	48	5.27	1.23	0.89	1.71
2007–2013	155	4.25

Confidence Interval