Rabies post-exposure prophylaxis for a child with severe allergic reaction to rabies vaccine

Figures & data

Figure 1. The rabies virus neutralizing antibody (RVNA) titers of a 4-year-old boy after being immunized with a liquid PVRV under Zagreb regimen, who showed severe allergic reaction to lyophilized PVRV because of the component of bull bone 7 d ago (−7), and thus had been treated with 3 days' anti-allergy therapy. RVNA titers in serum were measured under masked conditions using a rapid fluorescent focus inhibition test (RFFIT).^2,3 Reference data was adapted from the mean RVNA titers of local < 5-year-old children under Zagreb regimen in our previous study³

Table 1. The results of allergy testing.

Allergen Name	Concentration (kU/L)	Classification^#
Inhalant allergen screening	0.47	1
House dust	<0.35	0
House dust mite	0.44	1
Dust mite	0.41	1
Cat	<0.35	0
Oak pollen	<0.35	0
Elm pollen	<0.35	0
Plane pollen	<0.35	0
Willow pollen	<0.35	0
Black poplar pollen	<0.35	0
Penicillium	<0.35	0
Bud cladosporium	<0.35	0
Aspergillus fumigates	<0.35	0
Candida albicans	<0.35	0
Alternaria mold	<0.35	0
Helminthosporium mold	<0.35	0
Food allergen^*	1.16	2
Egg	0.70	2
Milk	0.73	2

Notes.

* Food allergen includes egg, milk, wheat, cod, soybean, peanut.

# Classification of specific IgE (sIgE): Phl p 0, < 0.35kU/L; Phl p 1, >=0.35kU/L; Phl p 2, >=0.70kU/L; Phl p 3, >=3.5kU/L; Phl p 4, >=17.5kU/L; Phl p 5, >=50kU/L; Phl p 6, >=100kU/L.

Fang Y, Chen L, Liu MQ, Zhu ZG, Zhu ZR, Hu Q. Comparison of safety and immunogenicity of PVRV and PCECV immunized in patients with WHO category II animal exposure: a study based on different age groups. PLoS Negl Trop Dis 2014; 8:e3412; PMID:25522244; http://dx.doi.org/10.1371/journal.pntd.0003412

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