Hepatitis B surface antibodies in medical students from a public university in Puebla, Mexico

Figures & data

Table 1. Demographic data of medical students from a public university in Puebla, Mexico.

Sex	N	%
Female	131	65.2
Male	70	34.8
Total	201	100.0
Risk factor
Mother HBV infected	0	0.0
Sexually active	92	45.9
More than 2 sexual partners	43	21.4
Clinical practice^*	63	32.6
Blood transfusion or organ transplant	1	0.49
Vaccination data
Vaccinated with 2 or 3 doses	74	36.8
Vaccinated with single dose	35	17.5
Unknown vaccination status^**	30	14.9
Unvaccinated	62	30.8
Total	201	100.0

* Having been exposed to blood or secretions of patients.

** No immunization record.

Table 2. Association between serological HBV markers and vaccination status in medical students from a public university in Puebla, Mexico.

	Serological marker, n (%)
	HBsAg		Anti-HBc		Anti-HBs
Vaccination status	Positive	Negative	Positive	Negative	Positive	Negative
2 or 3 doses	0 (0.0)	74 (100)	0 (0.0)	74 (100)	71 (95.9)	3 (4.1)
Single dose	0 (0.0)	35(100)	0 (0.0)	35 (100)	15 (42.8)	20 (57.2)
^*Unvaccinated	^*1 (1.6)	61 (98.4)	^*2 (3.2)	60 (96.8)	3 (4.8)	^*59 (95.2)
Unknown	0 (0.0)	30 (100)	0 (0.0)	30 (100)	7 (23.3)	23 (76.4)
Total	1 (0.5)	200 (99.5)	2 (1.0)	199 (99.0)	96 (47.8)	105 (52.2)
Prevalence (95%CI)	0.5 (0.43 – 0.57)		1.0 (0.87 – 1.14)		47.8 (40.2 – 53.8)

* One student was HBsAg (+), Anti-HBc (+) and Anti-HBs (−). *Other was HBaAg (−),

Anti-HBc (+) and Anti-HBs (−)

Table 3. Association of anti-HBs range (mIU/ml) and vaccination status in medical students from a public university in Puebla, Mexico.

	Anti-HBs ranges mIU/mL, n(%)						Anti-HBs, n(%)
Vaccination status	1.0–9.9	10–100	101–500	501–1000	1001–3000	>3000	Positive	Negative	Total
Vaccinated (2 or 3 doses)	2 (2.70)	13 (17.6)	27 (36.5)	6 (8.1)	17 (23.0)	6 (8.1)	71 (95.09)	3 (4.01)	74 (100)
Vaccinated ( single dose)	1 (2.9)	3 (8.6)	6 (17.1)	1 (2.9)	2 (5.8)	2 (2.9)	15 (42.9)	20 (57.1)	35 (100)
Unvaccinated	0 (0.0)	0 (0.0)	0 (0.0)	3 (4.8)	0 (0.0)	0 (0.0)	3 ( 4.80)	59 (95.2)	62 (100)
Unknown	0 (0.0)	3 (10.0)	2 (6.7)	2 (6. 7)	0 (0.0)	0 (0.0)	7 (23.4)	23 (76.6)	30 (100)
Total	3 (1.5)	19 (9.4)	35 (17.4)	12 (6.0)	19 (9.5)	8 (4.0)	96 (47.8)	105 (52.2)	201(100)

Table 4. Association between risk factors and anti-HBc status in medical students from a public university in Puebla, Mexico.

	Univariate analysis
Gender	Students, n	Anti-HBc (+), n (%)	Odds ratio (95% CI)	p
Male	131	1 (0.76)	1.87 (0.11–30.4)	1.00
Female	70	1 (1.42)
Sexually active
Yes	92	2 (2.17)	6.05 (0.28–128)	0.208
No	109	0 (0.00)
More than 2 sexual partners
Yes	43	2 (4.65)	19.9 (1.39–406)	0.044
No	158	0 (0.00)
Clinical practice
Yes	63	1 (1.58)	2.21 (0.13–35.9)	0.529
No	138	1 (0.72)
Blood transfusion or organ transplant
Yes	1	1 (100)	399 (11.1–1434)	0.010
No	200	0 (0.00)