Adenoviral vector-based strategies against infectious disease and cancer

Figures & data

Table 1. List of rAd vaccine candidates in clinical trials.

Pathogens	Ad vectors	Antigens	Study models	Clinical trials	References
HIV/SIV	AdHu5, AdHu26,AdHu35	Gag,Pol, Env,Nef,GRIN	Mice, nonhuman primates, humans	Yes	^51-58
Influenza virus	AdHu4, AdHu5,	HA	Mice, humans	Yes	^59-62
Ebola virus	Chimpanzee Ad3, AdHu5, AdHu26, AdHu35	GP	Mice, guinea pigs, nonhuman primates, humans	Yes	^72-78
Mycobactrium tuberculosis	AdHu5,AdHu35	CFP10, ESAT6, Ag85A, Ag85B, TB10.4	Mice, nonhuman primates, humans	Yes	^79-82
Plasmodium falciparum	AdHu5, AdHu35, Chimapanzee Ad63	AMA1,MSP1,CSP	Mice, nonhuman primates, humans	Yes	^83-88

Table 2. List of rAd vaccine candidates in pre-clinical trials.

Pathogens	Ad vectors	Antigens	Study models	Clinical trials	References
Rabies virus	AdHu5, Canine Ad type 2,AdC68	GP	Mice, fox, dog, sheep, nonhuman primates	No	^63-66
Dengue virus	AdHu5	E, prM	Mice, nonhuman primates	No	^67-69
MERS	AdHu5, AdHu41	S	Mice	No	^70,71