Immunogenicity and safety of different schedules of 2-dose varicella vaccination in China

Figures & data

Table 1. Characteristics of the four groups of study participants in Zhejiang province, China.

	Group 1 n = 312	Group 2 n = 249	Group 3 n = 249	Group 4 n = 268
Interval between two doses	3 months	1 year	3 years	5 years
Median age (Q25,Q75)
Age in months at 1st dose	12 (12,13)	12 (12,13)	12 (12,13)	13 (12,16)
Age in months at 2nd dose	15 (15,16)	25 (25,26)	49 (49,50)	74 (73,77)
Gender, n (%)
Male	183 (58.65%)	142 (57.03%)	123 (49.40%)	138 (51.49%)
Female	129 (41.35%)	107 (42.97%)	126 (50.60%)	130 (48.51%)

Table 2. Comparison of immunization effects of the second dose of varicella vaccine among the four groups.

	Pre-2nd vaccination		Post-2nd vaccination
Group	GMT^a (95% CI)	SR^b (%)	GMT (95% CI)	SR (%)	SCR^c (%)
Group 1	20.52 (4.88-86.32)	100	51.14 (12.72-205.63)	100	40.38
Group 2	14.68 (5.68-37.93)	100	83.37 (29.96-232.02)	100	88.35
Group 3	12.49 (2.12-73.67)	99.6	85.01 (13.52-534.55)	100	82.33
Group 4	12.29 (2.01-75.28)	98.88	81.83(15.16-441.79)	100	85.07
Coefficient value	χ^2 = 71.243	4.422^d	χ^2 = 96.065	—	χ^2 = 224.888
p-value	0.000	0.093	0.000	—	0.000

^a GMT: Geometric mean titer

^b SR: Seropositivity Rate

^c SCR: Seroconversion Rate

^d Fisher's Exact Test