Figures & data
Figure 1. Schematic of rational HIV immunogen design based on natural infection. Env glycoprotein immunogens are rationally designed based on Abs isolated from an HIV infected individual that displays broad neutralization. Vaccine strategies entail cocktail vaccination to elicit bNAbs against a conserved site among different Env proteins. Or sequential vaccination with Env immunogens designed based on a developing bNAb lineage. Subsequent animal immunizations with the designed Env proteins and iterative vaccine design will guide optimization of the immunogen through isolation and characterization of NAbs from immunized animals, providing detailed knowledge on germline usage and target epitope. Which will in turn improve the Env protein immunogen design, improving it to elicit bNAbs.
