Assessing the risk of intussusception and rotavirus vaccine safety in Canada

Figures & data

Figure 1. Overall annual intussusception admission rates in Canadian infants by year and 95% confidence limits adjusted for age group, sex and region 2003-2013.

Figure 2. Annual intussusception admissionrates and 95% confidence intervals in infants by region adjusted for age group, sex and year 2003-2013.

Figure 3. Annual intussusception admission rates and 95% confidence intervals in infants by age group in months, adjusted for calendar year, sex and region 2003-2013*. *P < 0.0001 for a differential effect by age group.

Table 1. Publicly Funded Rotavirus programs in Canada, excluding Quebec.

Jurisdiction	Program	Start Date	RV jurisdiction	Total IS Cases 2003–2013	Total Infants <1 2013	Total person-years for infants < 1 2003-2013
British Columbia (BC)	Yes	Jan. 1, 2012	Yes	118	43,565	453,030
Alberta (AB)	Yes	June 1 2015	No	122	52,018	494,828
Saskatchewan (SK)	Yes	Nov 1 2012	Yes	30	14,832	141,106
Manitoba (MB)	Yes	Apr 1, 2014	No	39	15,748	158,158
Ontario (ON)	Yes	Aug 11, 2011	Yes	405	136,400	1,468,427
New Brunswick (NB)	No	—	No	15	7,321	76,609
Nova Scotia (NS)	No*	—	No	31	8,689	93,099
Newfoundland and Labrador (NL)	Yes	Sept 1, 2015	No	38	4,819	50,187
Prince Edward Island (PEI)	Yes	Dec 1, 2010	Yes	3	1,405	14,404
Yukon Territory (YT)	Yes	Oct 1 2012	Yes	1	416	3,921
Northwest Territories (NT)	Yes	Fall 2013	No	2	636	7,231
Nunavut (NU)	No	—	No	6	747	7,594

* Although NS does not have a publicly funded RV program, the Halifax metro area (which accounts for half the population of NS) did have a universal rotavirus program for approximately 2 y during the study period, although the vaccine coverage achieved was low, never exceeding 40% (32)

As per: http://www.phac-aspc.gc.ca/im/ptimprog-progimpt/table-1-eng.php (accessed March 16, 2016 and current as of February 3, 2016)

Sask: http://www.gov.sk.ca/news?newsId=f4ec0c5b-401d-4d59-be4d-3eee346e5e9c

YT: http://archive-ca.com/page/4365002/2014-07-29/http://www.hss.gov.yk.ca/12-183.php; http://www.hss.gov.yk.ca/pdf/im_manual_section1.pdf

Table A1. Sensitivity Analysis: Estimated IS Rates before vs. after RV Program Introduction 1) Overall, 2) In 2−<8 month-olds, 3) In 2−<6 month-olds, 4) In 2−<4 month-olds, 2003-2013.

Analysis		Estimate of Rate of IS (95% CI)	p-value for difference before versus after
Overall	Before	23.4 (21.5, 25.4)
	After	22.4 (18.3, 27.4)	0.70
2−<8 months-olds	Before	35.1 (32.0,38.7)
	After	31.9 (24.8, 41.0)	0.47
2−<6 month-olds	Before	34.3 (30.5, 38.7)
	After	31.6 (23.1, 43.1)	0.61
2−<4 month-olds	Before	31.5 (26.4, 37.5)
	After	27.6 (17.1, 44.5)	0.60