Effectiveness of hepatitis A vaccination as post-exposure prophylaxis

Figures & data

Table 1. Characteristics of outbreaks by setting. Catalonia, 2006–2012.

Setting	No. of outbreaks	No. of exposed persons	Mean of exposed persons by outbreak	No. of secondary cases	Mean of secondary cases by outbreak
Family	70	549	7.8	110	1.6
Family and school	14	597	42.6	6	0.4
School	13	1336	102.8	28	2.1
Wider community	8	50	6.3	15	1.9
Family and day care center	4	343	85.8	33	8.2
Day care center and school	2	579	289.5	6	3
Day care center	1	96	96.0	6	6.0
Total	112	3550	31.7	204	1.8

Table 2. Distribution of outbreaks according to setting and type of post-exposure prophylaxis. Catalonia, 2006–2012.

Setting	IG	Vaccine	IG and vaccine	No post-exposure prophylaxis	Total
Family	6	20	27	17	70
Family and school	1	8	4	1	14
Family and day care center	0	2	1	1	4
Day care center and school	0	1	1	0	2
School	2	4	7	0	13
Day care center	0	0	1	0	1
Wider community	0	3	2	3	8
Total	9	38	43	22	112

Table 3. Effectiveness of post-exposure prophylaxis measures in outbreaks studied. Catalonia, 2006–2012.

Post-exposure prophylaxis	Exposed persons	Secondary cases	Rate of secondary cases (%)	Rate Ratio (95% CI)	Effectiveness (95% CI)	p
Any hepatitis A vaccine	2.381	17	0.71	0.024 (0.014–0.038)	97.6 (96.2–98.6)	<0.01
Hepatitis A vaccine	2.316	17	0.73	0.024 (0.014–0.039)	97.6 (96.1–98.6)	<0.01
Hepatitis A+B vaccine	65	0	0	0.00 (0.00–0.154)	100 (84.6–100)	<0.01
Immune globulin	190	1	0.53	0.017 (0.001–0.087)	98.3 (91.3–99.9)	<0.01
No post-exposure prophylaxis	611	184	30.11	Ref.	Ref.
Total	3.182	202	6.35