Economic burden of pneumococcal infections in children under 5 years of age

Figures & data

Table 1. Direct and indirect costs for the treatments of the study population.

		Pneumococcal Meningitis n = 10	Pneumonia n = 53	Acute Otitis Media n = 67
Direct costs, €	Mean ± SD	9,299.98 ± 13,762.01	1,317.76 ± 3,179.1	20.57 ± 7.64
	Median (Q1-Q3)	3,346.38 (941.82–11,700.86)	480.66 (202.36–891.13)	17.59 (17.59–17.59)
Service cost	Mean ± SD	6,889.99 ± 11,532.51	879.84 ± 2,255.03	NA
	Median (Q1-Q3)	1,794.41 (648.83–8,914.87)	296.69 (175.60–574.53)	NA
Medication cost	Mean ± SD	1,719.31 ± 2,698.07	331.92 ± 1,142.81	NA
	Median (Q1-Q3)	485.24 (275.35–2,068.33)	68.2 (31.33–230.44)	NA
Material cost	Mean ± SD	690.68 ± 1,170.44	106 ± 324.31	NA
	Median (Q1-Q3)	322.84 (24.16–615.96)	8.08 (1.84–50.88)	NA
Indirect costs, €	Mean ± SD	2,472.32 ± 3,078.55	474.23 ± 448.67	106.15 ± 30.45
	Median (Q1-Q3)	829.18 (483.65–3,255.39)	330.09 (214.91–560.44)	99.73 (99.73–99.73)
Total Cost, €	Mean ± SD	11,772.3 ± 16,688.16	1,792.00 ± 3,472.51	126.72 ± 36.07
	Median (Q1-Q3)	4,060.38 (1,463.87–14,959.24)	835.91 (405.31–1,458.12)	117.32 (117.32–117.32)

SD, standard deviation; Q1, 1^st quartile (25^th percentile); Q3, 3^rd quartile (75^th percentile); NA, not available

Table 2. Comparison of costs according to age in the patients with pneumonia and acute otitis media.

		Pneumonia			Acute otitis media
		<36 months n = 21	≥36 months n = 32	p	<36 months n = 40	≥36 months n = 27	p
Direct Costs, €	Mean ± SD	397.65 ± 247.43	1,921.59 ± 3,995.47	0.061	22.08 ± 9.33	18.33 ± 3.00	0.049
	Median (Q1-Q3)	285.38 (202.36–522.01)	601.27 (235.23–1,885.74)		17.59 (17.59–22.93)	17.59 (17.59–17.59)
Service cost	Mean ± SD	284.35 ± 156.53	1,270.62 ± 2,848.92	0.056	NA	NA	—
	Median (Q1-Q3)	217.77 (175.60–348.18)	438.28 (181.09–999.65)
Medication cost	Mean ± SD	81.74 ± 78.69	496.1 ± 1,454.83	0.047	NA	NA	—
	Median (Q1-Q3)	53.11 (30.29–97.02)	113.66 (36.67–388.87)
Material cost	Mean ± SD	31.55 ± 64.53	154.86 ± 409.29	0.490	NA	NA	—
	Median (Q1-Q3)	8.08 (1.43–18.40)	6.83 (2.45–84.68)
Indirect Costs, €	Mean ± SD	300.83 ± 141.53	588.03 ± 539.45	0.032	109.52 ± 38.78	101.16 ± 7.39	0.215
	Median (Q1-Q3)	291.69 (176.52–368.48)	406.87 (214.91–752.4)		99.73 (99.73–99.73)	99.73 (99.73–99.73)
Total Cost, €	Mean ± SD	698.48 ± 375.22	2,509.62 ± 4,335.26	0.011	131.32 ± 45.51	119.49 ± 10.26	0.051
	Median (Q1-Q3)	577.08 (378.88–927.09)	1,031.36 (545.02–2,772.51)		117.32 (117.32–122.67)	117.32 (117.32–117.32)

SD, standard deviation; Q1, 1^st quartile (25^th percentile); Q3, 3^rd quartile (75^th percentile); NA, not available

Table 3. Comparison of costs according to gender in the patients with pneumonia and acute otitis media.

		Pneumonia			Acute Otitis Media*
		Girl n = 25	Boy n = 28	p	Girl n = 25	Boy n = 42	p
Direct Costs, €	Mean ± SD	666.97 ± 856.55	1,898.83 ± 4,250.92	0.165	20.39 ± 7.1	20.67 ± 8.03	0.696
	Median (Q1-Q3)	272.15 (190.40–649.63)	534.59 (299.37–1,023.96)		17.59 (17.59–17.59)	17.59 (17.59–17.59)
Service cost	Mean ± SD	428.36 ± 478.09	1,282.95 ± 3038.63	0.247	NA	NA	—
	Median (Q1-Q3)	217.77 (152.72–447.31)	318.81 (200.06–743.65)
Medication cost	Mean ± SD	151.83 ± 238.16	492.71 ± 1551.79	0.101	NA	NA	—
	Median (Q1-Q3)	55.38 (29.73–123.62)	86.7 (36.67–257.26)
Material cost	Mean ± SD	86.78 ± 310.15	123.17 ± 341.18	0.345	NA	NA	—
	Median (Q1-Q3)	5.95 (1.18–20.25)	8.91 (1.89–84.68)
Indirect Costs, €	Mean ± SD	389.98 ± 308.75	549.47 ± 539	0.136	104.34 ± 12.73	107.23 ± 37.34	0.781
	Median (Q1-Q3)	291.69 (176.52–560.44)	368.48 (253.3–598.83)		99.73 (99.73–99.73)	99.73 (99.73–99.73)
Total Cost, €	Mean ± SD	1,056.94 ± 1,068.04	2,448.30 ± 4,611.13	0.130	116.61 ± 19.00	127.90 ± 43.26	0.722
	Median (Q1-Q3)	743.29 (361.02–1,210.07)	901.59 (590.03–1,799.23)		109.33 (109.33–109.33)	117.32 (117.32–117.32)

SD, standard deviation; Q1, 1^st quartile (25^th percentile); Q3, 3^rd quartile (75^th percentile); NA, not available