Rabies post-exposure prophylaxis for a male with severe Henoch Schönlein purpura following rabies vaccination

Figures & data

Figure 1. The rabies virus neutralizing antibody (RVNA) titers of a male with severe HSP following rabies vaccination, and received a new anti-rabies programe 15 days later.

Table 1. Patient presentation of vaccine, adverse events and treatment.

Days post vaccination	Vaccine	Dose	AEs	Treatment
0	PVCV vaccine A	1 Dose	Fever (37.5℃) within 5 hours after vaccination	Fever relieved within 12 to 24 hours without treatment
3	PVCV vaccine A	1 Dose	Fever (38.2℃) within 3 hours	Fever relieved within 24 to 48 hours without treatment
7	PVCV vaccine A	1 Dose	Allergic purpura and fever (38.9℃ at 2 hours, 39.1℃ at 4 hours)	Steroid therapy
14	—		—	Allergy testing
15	PVCV vaccine B	2 Dose	No new AEs occur	—
21	PVCV vaccine B	1 Dose	No new AEs occur	—
35	PVCV vaccine B	1 Dose	No new AEs occur	—

Table 2. The results of allergy testing.

Allergen Name	Concentration (kU/L)	Classification
Inhalant allergen screening	< 0.35	0
House dust	< 0.35	0
House dust mite	0.39	1
Dust mite	< 0.35	0
Cat	< 0.35	0
Oak pollen	< 0.35	0
Elm pollen	< 0.35	0
Plane pollen	< 0.35	0
Willow pollen	< 0.35	0
Black poplar pollen	0.40	1
Penicillium	< 0.35	0
Bud cladosporium	< 0.35	0
Aspergillus fumigates	< 0.35	0
Candida albicans	< 0.35	0
Alternaria mold	< 0.35	0
Helminthosporium mold	< 0.35	0
Food allergen	< 0.35	0
Agg	< 0.35	0
Milk	< 0.35	0

Notes. Food allergen includes egg, milk, wheat, cod, soybean, peanut.

^# Classification of specific IgE (sIgE): Phl p 0, < 0.35kU/L; Phl p 1, ≧0.35kU/L; Phl p 2, ≧0.70kU/L; Phl p 3, ≧3.5kU/L; Phl p 4, ≧17.5kU/L; Phl p 5, ≧50kU/L; Phlp 6, ≧100kU/L.

Table 3. Properties of 2 different rabies vaccines.

	Vaccine A	Vaccine B
Cell types	Vero cell	Vero cell
Dosage(ml)	1.0	0.5
Formation	lyophilized	lyophilized
Production	bioreactor	bioreactor
Strains	aG	PV2061
Inactivated form	β-propiolactone	β-propiolactone
Excipient	Saccharose	Dextran
Residues	gentamycin	—