Economic burden of varicella complications in two referral centers in Mexico

Figures & data

Table 1. Demographic and clinical characteristics of study population.

Parameter	Cases (n = 172)	Contacts (n = 121)	Total (n = 294)
Participating hospital
HIMFG	100	-	100
INP	72	121	194
Sex
Females, n (%)	73 (42.4%)	53 (43.8%)	126 (43.0%)
Males, n (%)	99 (57.6%)	68 (56.2%)	167 (57.0%)
Age group
< 1 year, n (%)	10 (5.8%)	45 (37.2%)	55 (18.8%)
1–4 years, n (%)	68 (39.5%)	40 (33.1%)	108 (36.9%)
5–9 years, n (%)	58 (33.7%)	19 (15.7%)	77 (26.3%)
10–17 years, n (%)	36 (20.9%)	17 (14.1%)	53 (18.1%)
Source of contagious contact
Outside hospital, n (%)	52 (71%)	5 (4%)	57 (29%)
In hospital, n (%)	21 (29%)	116 (96%)	137 (71%)
Year
2011, n (%)	2 (1.2%)	0	2 (0.7%)
2012, n (%)	57 (33.1%)	43 (33.5%)	100 (34.1%)
2013, n (%)	54 (31.4%)	37 (30.6%)	91 (31.1%)
2014, n (%)	59 (34.3%)	41 (33.9%)	100 (34.1%)
Other
Previous varicella vaccination, n (%)	3 (1.7%)	5 (4.1%)	8 (2.7%)
Presence of co-morbidities, n (%)	154 (89.5%)	107 (88.4%)	261 (89.1%)

HIMFG, Hospital Infantil de México Federico Gomez; INP, Instituto Nacional de Pediatría, n, number of cases

Table 2. Complications of varicella cases.

Complications	Cases N = 172	Contacts N = 121	Total N = 293
None, n (%)	134 (77.9%)	121 (100%)	255 (87.6%)
Any complication, n (%)	38 (22.1%)	-	38 (13.4%)
Severe sepsis and septic shock, n	15	0	15
Low respiratory tract, n	8	0	8
Skin and soft tissue, n	7	0	7
Neurological, n	5	0	5
Hemorrhagic varicella, n	1	0	1
Nosocomial sepsis, n	1	0	1
Bacterial superinfection, n	1	0	1

n, number of cases

Table 3. Hospital resource use and cost for varicella hospitalizations.

	Cases (n = 172)	Contacts (n = 121)	Estimated cost per day/unit, MXN
Median hospitalization, days (SD; percentile 10th – 90th)	12 (133.1; 5 – 53)	13 (17.3; 3 – 44)	6881
Antivirals, % (n)	89.0% (n = 153)	64.5% (n = 78)	403
Intravenous	82.6% (n = 142)	43.0% (n = 52)	415
Oral	19.8% (n = 34)	29.8% (n = 36)	10
Mean days (SD; range)	8.4 (4.1; 1–20)	6.1 (3.3; 1–19)
Immunoglobulin intravenous, % (n)	2.3% (n = 4)	0	6690
Antibiotics, % (n)	34.9% (n = 60)	0
Serology, % (n)	1.4% (n = 1)	0	920
X-rays, % (n)	26.9% (n = 46)	0	441
Cultures, % (n)	30.2% (n = 52)	0	755
Intensive care unit, % (n)	12.8% (n = 22)	0	33,911

MXN, Mexican peso; SD, standard deviation; n, number of cases

Figure 1. Duration of Hospital Stay for Varicella-Confirmed Cases and Varicella Contacts By Age Group. Box: median with 25th and 75th percentiles; Whiskers: upper/lower adjacent values; Data points: outside values.

Table 4. Varicella international classification of diseases ninth or tenth revision (ICD-9 or ICD-10).

ICD-9 codes	ICD-10 codes
052 Chickenpox;	B01 Varicella (chickenpox);
052.0 Postvaricella encephalitis;	B01.0 Varicella meningitis;
052.1 Varicella (hemorrhagic) pneumonitis;	B01.1 Varicella encephalitis, myelitis and encephalomyelitis;
052.2 Postvaricella myelitis; 052.7 Chickenpox with other specified complications convert;	B01.11 Varicella encephalitis and encephalomyelitis;
052.8 Chickenpox with unspecified complication;	B01.12 Varicella myelitis;
052.9 Varicella without mention of complication.	B01.2 Varicella pneumonia; B01.8 Varicella with other complications; B01.81 Varicella keratitis;
	B01.89 Other varicella complications; B01.9 Varicella without complication.