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Human Vaccines & Immunotherapeutics Volume 15, 2019 - Issue 3
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Research Paper

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV-15) compared to PCV-13 in healthy older adults

Helen L. StaceyDiablo Clinical Research, Inc, Walnut Creek, CA, USAORCID Iconhttp://orcid.org/0000-0003-1919-0302View further author information
ORCID Icon,
Jeffrey RosenClinical Research of South Florida, Coral Gables, FL, USAView further author information
,
James T. PetersonJ. Lewis Research, Inc./Foothill Family Clinic, Salt Lake City, USAView further author information
,
Angela Williams-DiazMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Vanita GakharMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Tina M. SterlingMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Camilo J. AcostaMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Katrina M. NolanMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAORCID Iconhttp://orcid.org/0000-0001-5030-7930View further author information
ORCID Icon,
Jianing LiMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Alison PedleyMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Patrice BennerMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Chitrananda AbeygunawardanaMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Michael KosinskiMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
William J. SmithMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
,
Hari PujarMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USAView further author information
&
Luwy K. MuseyMerck & Co., Inc., Merck Research Laboratories, Kenilworth, NJ, USACorrespondence[email protected]
View further author information
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Pages 530-539 | Received 07 Jun 2018, Accepted 25 Sep 2018, Published online: 16 Jan 2019

Figures & data

Table 1. Subjects reporting local and systemic adverse events within 14 days postvaccination.

Figure 1. Subject disposition.

Figure 1. Subject disposition.

Figure 2. PCV15-A and PCV15-B versus PCV13 OPA GMT ratios at 1 month postvaccination.

Figure 2. PCV15-A and PCV15-B versus PCV13 OPA GMT ratios at 1 month postvaccination.

Figure 3. PCV15-A and PCV15-B versus PCV13 IgG GMC ratios at 1 month postvaccination.

Figure 3. PCV15-A and PCV15-B versus PCV13 IgG GMC ratios at 1 month postvaccination.

Table 2. Summary of OPA antibody responses – geometric mean fold rise (GMFR) (per protocol population).

Table 3. Summary of IgG antibody responses – GMFR (per protocol population).

Table 4. Summary of OPA antibody responses – %≥ 4 fold rise (per protocol population).

Figure 4. Serotype-specific OPA GMTs by age stratum [PCV15-A (left); PCV15-B (right)]

Figure 4. Serotype-specific OPA GMTs by age stratum [PCV15-A (left); PCV15-B (right)]
Supplemental material

Supplemental Material

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