Figures & data
Figure 1. The dual roles of HBeAg. (a). Serum HBeAg inhibits spontaneous IgG anti-HBc Ab production in vivo in a HBc-Tg lineage that is not tolerant to the HBcAg. IgG anti-HBc Ab was measured in the serum of six HBc-Tg and six HBc × HBe double-Tg (dbl-Tg) mice on a genetic background of a HBe/HBcAg-specific, CD4+ TCR-Tg strain. Adapted from Ref. [6]. (b). Liver injury persists longer when the HBcAg and HBeAg are co-expressed in the liver. To mimic the period when HBeAg-specific tolerance is subsiding, activated polyclonal HBc/HBeAg-specific CTL cells were transferred into HBc-Tg or HBc × HBe dbl-Tg mice recipients and serum ALT levels were measured as a marker of liver injury. Adapted from Ref. [33].
![Figure 1. The dual roles of HBeAg. (a). Serum HBeAg inhibits spontaneous IgG anti-HBc Ab production in vivo in a HBc-Tg lineage that is not tolerant to the HBcAg. IgG anti-HBc Ab was measured in the serum of six HBc-Tg and six HBc × HBe double-Tg (dbl-Tg) mice on a genetic background of a HBe/HBcAg-specific, CD4+ TCR-Tg strain. Adapted from Ref. [6]. (b). Liver injury persists longer when the HBcAg and HBeAg are co-expressed in the liver. To mimic the period when HBeAg-specific tolerance is subsiding, activated polyclonal HBc/HBeAg-specific CTL cells were transferred into HBc-Tg or HBc × HBe dbl-Tg mice recipients and serum ALT levels were measured as a marker of liver injury. Adapted from Ref. [33].](/cms/asset/c21add42-80ae-4028-ac4e-45c44839425e/khvi_a_1607132_f0001_b.gif)