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Research Paper

Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) in adults 56 years of age and older: a Phase II randomized study

ORCID Icon, , , & ORCID Icon
Pages 1299-1305 | Received 20 Dec 2019, Accepted 19 Feb 2020, Published online: 01 Apr 2020

Figures & data

Table 1. Baseline demographics (all participants).

Table 2. Proportions of participants achieving hSBA titers ≥1:8 at baseline (Day 0) and at Day 30 post-vaccination against serogroups A, C, W, and Y by vaccine group (PPAS).

Figure 1. Proportion of participants with an hSBA vaccine seroresponse* at Day 30 (PPAS) *Vaccine seroresponse is defined as a post-vaccination titer ≥1:8 if baseline titer is <1:8 at baseline or a ≥4-fold increase if baseline titer is ≥1:8.

Figure 1. Proportion of participants with an hSBA vaccine seroresponse* at Day 30 (PPAS) *Vaccine seroresponse is defined as a post-vaccination titer ≥1:8 if baseline titer is <1:8 at baseline or a ≥4-fold increase if baseline titer is ≥1:8.

Table 3. Geometric mean antibody titers against serogroups A, C, W, and Y at baseline (Day 0) and Day 30 post-vaccination, as assessed by hSBA and rSBA (PPAS).

Figure 2. Proportion of participants with rSBA titers ≥1:128 at (a) baseline and (b) Day 30 (PPAS).

Figure 2. Proportion of participants with rSBA titers ≥1:128 at (a) baseline and (b) Day 30 (PPAS).

Table 4. Summary of safety data from Day 0 to Day 30 post-vaccination with MenACYW-TT or MPSV4 (safety analysis set).

Supplemental material

Supplemental Material

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