Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018

Figures & data

Table 1. The site of infection according to the years

	Study period
	2008–2010	2011–2012	2013–2014	2014–2018
The site of infection	n (%)	n (%)	n (%)	n (%)
Bacteremia/sepsis	100 (49.5)	33 (49.2)	37 (56)	104 (62.2)
Meninjitis	63 (31.2)	26 (38.8)	18 (27.3)	52 (31.1)
Empiyema	39 (19.3)	8 (12)	11 (16.7)	11 (6.6)

Table 2. Serotype distribution of Streptococcus pneumoniae according to clinical samples and vaccination status

							Vaccine doses
	Isolate number (n)	Blood	CSF	Empyema	Others	Number of patients	7	13	Unvaccinated
PCV–7	42	28	11	1	2
19F	20	14	3	1	2	2	–	3	2
						1	–	1
						2	1	3
						4	4	–
						9	–	4
23F	7	4	3	–	–	1	1	–	4
						1	4	–
						1	–	4
4	4	2	2	–	–	1	–	1	2
						1	4	–
6B	2	0	2	–	–	1	–	3	1
9V	4	4	0	–	–	1	4	–	1
						1	–	4
						1	–	3
14	4	4	0	–	–	2	–	4	–
						1	–	3
						1	–	2
18C	1	0	1	–		–	–	–	1
PCV–10	61	12	6	1	–
1	18	11	6	1	–	3	–	3	4
						1	–	1
						4	4	–
						2	2	2
						1	1	3
						2	–	4
						1	3	1
5	1	1	–	–	–	–	–	–	1
7F	0	–	–	–	–	–	–	–	–
PCV–13	94	18	7	8	–
3	17	11	1	5	–	1	4	–	4
						11	–	4
						1	–	1
6A	9	5	3	1	–	1	4	–	5
						2	–	4
						1	–	3
19A	7	2	3	2	–	3	4	–	3
						1	2	2
Non-vaccine types	73	46	25	1	1
8	5	4	2	1	–	**			26
10A	5	3	1	–	1	29	8	–
11A	3	3	0	–	–	1	3	–
12F	5	3	1	–	–	2	2	1
15B	6	3	3	–	–	10	–	2
15C	3	3	–	–	–	3	–	3
15F	3	0	–	–	–	2	–	2
20	3	2	1	–	–			1
Others	40	27	17	–	–

*Only one sample was taken from each patient.

^¥Joınt fluid

**Number of patients and doses are not for each serotype, data are for total nonvaccine serotypes.

The total number of isolates, the number of each site of isolates, the distribution of each serotypes and the number of patients with PCV13 or PCV7 vaccine doses before IPD were shown in Table 2.

Figure 1. Vaccine serotype coverage rates for PCV7, PCV10 and PCV13 before and after the inclusion of PCV7 and PCV13 in Turkey’s NIP according to the years

Table 3. Penicillin-resistance rate of serotypes

	Penicillin-resistance rate (%)
PCV7 s
19 F	20
23 F	67
4	50
6B	100
9 V	0
14	0
18 C	100
PCV10 s
1	38
5	0
7 F	50
PCV13
3	6
6A	33
19A	43
PCV13 serotypes	29
Non-PCV13 serotypes	38