Synchrony in serum antibody response to conserved proteins of Moraxella catarrhalis in young children

Figures & data

Table 1. Demographics of the subjects

Item	N (% of total)	Item	N (% of total)
Sex		Daycare
Male	53 (44.3%)	None	84 (70.9%)
Female	66 (55.7%)	Home or Center	35 (29.1%)
Ethnicity		Smokers in the Home
White	98 (82.3%)	Yes	9 (7.6%)
African Am.	7 (6.3%)	No	110 (92.4%)
Other	14 (11.4%)	Familial History of AOM
OM susceptibility^a		Yes	58 (48.7%)
NOP	83 (69.6%)	No	61 (51.3%)
sOP	36 (30.4%)	Sibling Status
Breastfeeding		No siblings	50 (41.8%)
< 6 months	72 (60.8%)	≤ 5 years old	56 (46.8%)
≥ 6 months	47 (39.2%)	> 5 years old	6 (5.1%)
Atopy		< 5 years and >5 years	7 (6.3%)
Yes	38 (31.6%)
No	81 (68.4%)

^aNOP, non-otitis prone; sOP, stringently defined otitis prone.

Figure 1. Serum IgG antibody response to Mcat proteins OppA (A), Hag5-9 (truncated Hag protein, B), OMP CD (C), PilA2 (D) and Msp22NL (non-lipidated Msp22, E) in NOP children age 6–30 months. Serum IgG antibody concentrations (ng/mL) were determined with a quantitative ELISA and then logarithm transformed. Mean (solid lines) and 95% confidence intervals (dashed lines) are shown. Functional estimates of log10 concentration against age were obtained using a linear mixed effects model. A total of 149 time points from 85 subjects were analyzed. Small circles represent IgG data

Figure 2. Serum IgG antibody response to Mcat proteins OppA (A), Hag5-9 (truncated Hag protein, B), OMP CD (C), PilA2 (D) and Msp22NL (non-lipidated Msp22, E) in sOP children age 6–30 months. Serum IgG antibody concentrations (ng/mL) were determined with a quantitative ELISA and then logarithm transformed. Mean (solid lines) and 95% confidence intervals (dashed lines) are shown. Functional estimates of log10 concentration against age were obtained using a linear mixed effects model. A total of 66 time points from 34 subjects were analyzed. Small circles represent IgG data