Immunogenicity of an Escherichia coli-produced bivalent human papillomavirus vaccine under different vaccination intervals

Figures & data

Table 1. Baseline characteristics of the immunogenicity subgroups (per-protocol set).

	28-40d		41-50d		51-60d		Total
2^nd interval	N	average age $\left(\bar{X}\pm S\right)$	N	average age$\left(\bar{X}\pm S\right)$	N	average age $\left(\bar{X}\pm S\right)$	N	average age$\left(\bar{X}\pm S\right)$
103-139 d	353	30.9±7.34	498	32.7±7.71	279	29.2±7.01	1130	31.3±7.55
140-160 d	288	30.3±7.16	388	30.8±7.50	24	26.3±5.42	700	30.5±7.34
161-198 d	88	28.8±7.16	106	29.4±7.25	2	27±4.24	196	29.1±7.17
Total average age	729	30.4±7.26	992	31.6±7.66	305	29.0±6.94	2026	30.8±7.47
HPV-18
103-139 d	428	30.7±7.46	608	32.3±7.61	323	29.2±7.15	1359	31.1±7.56
140-160 d	338	30.8±7.23	480	30.7±7.42	32	26.8±5.92	850	30.6±7.33
161-198 d	114	28.8±6.99	119	29.9±7.53	2	23.5±0.71	235	29.3±7.26
Total average age	880	30.5±7.33	1207	31.5±7.58	357	28.9±7.06	2444	30.7±7.46

Figure 1. Reverse cumulative curves for IgG antibody levels of the different vaccination interval groups (per-protocol set) at month 7. Panel 1A: HPV-16 IgG antibody levels of the three groups with different 1^st intervals; Panel 1B: HPV-16 IgG antibody levels of the three groups with different 2^nd intervals; Panel 1 C: HPV-18 IgG antibody levels of the three groups with different 1^st intervals; Panel 1D: HPV-18 IgG antibody levels of the three groups with different 2^nd intervals.

Table 2. Analysis of antibody levels and GMC ratios in the subgroups (per-protocol set).

Vaccination intervals		Anti-HPV-16			Anti-HPV-18
1^st interval	2^nd interval	n	GMC (IU/mL)	GMC ratio* (95% CI)	n	GMC (IU/mL)	GMC ratio* (95% CI)
28-40d	140-160d	288	883.7	-	338	257.5	-
28-40d	103-139d	353	767.9	0.88 (0.79,0.99)	428	284.2	1.10 (0.98,1,23)
28-40d	161-198d	88	803.9	0.89 (0.75,1.05)	114	244.4	0.91 (0.77,1.08)
41-50d	140-160d	388	832.7	0.95 (0.86,1.06)	480	271.3	1.07 (0.96,1.18)
41-50d	103-139d	498	758.9	0.90 (0.81,1.00)	608	280.7	1.13 (1.02,1.25)
41-50d	161-198d	106	774.5	0.86 (0.73,1.00)	119	218.2	0.83 (0.71,0.97)
51-60d	140-160d	24	874.5	0.89 (0.64,1.23)	32	260.5	1.05 (0.78,1.41)
51-60d	103-139d	279	779.5	0.86 (0.77,0.97)	323	283.6	1.07 (0.96,1.21)
51-60d	161-198d	2	-	-	2	-	-

GMC: Geometric mean concentration.

* The standard vaccination schedule (a 1^st interval of 28–40 d and a 2^nd interval of 140–160 d) was set as the reference subgroup. GMC ratios were the GMC of each subgroup compared with that of the reference subgroup.

Supplementary information