https://orcid.org/0000-0002-3559-5548 & https://orcid.org/0000-0002-0589-5523Figure 1. The spike protein of the coronavirus binds to ACE2 on target cells (include lung and gastrointestinal tissues in the human body) leading to cell entry. The sACE2-anti-CD16 VHH bi-specific molecule not only blocks SARS-CoV-2 from infecting cells but also mediates ADCC by NK cells. Anti-CD16 VHH fused to soluble ACE2 would prolonged the construct circulation half-life in the body
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