Impact of refusal to vaccine in the neonatal period on the implementation of the vaccination calendar in the first year of life

Figures & data

Table 1. Polish Calendar of Vaccinations in the first year of life (mandatory, refundable vaccinations)

First year of life	Vaccine
	BCG	HBV	DTP	IPV	HiB
1. day of life	one dose	first dose
2. month of life		second dose	first dose		first dose
3. – 4. month of life			second dose	first dose	second dose
5. – 6. month of live			third dose	second dose	third dose
7. month of life		third dose

BGC – tuberculosis vaccine

HBV – hepatitis B vaccine

DTP – dyphteria, tetanus and pertussis vaccine

IPV – inactivated poliomyelitis vaccine

HiB – Hemophilus influenzae type b vaccine

Table 2. Including and excluding criteria of patients for the study

No.	Including criteria	Excluding criteria
1.	The full-term newborns	Preterms and neonates born after term of delivery
2.	Eutrophic newborn. Birth weight above 2000 g. The weght below 2000 g is contraindication to vaccination against TB.	Hypotrophic and hypertrophic newborns. birth weight below 2000 g.
3.	Healthy newborns	Newborns, whose staing in hospital after birth was complicated.
4.	Newborns, who were born in good codition (which means that they have received more than 7 points in Apgar scores)	Newborns, who received after 1 minutes of life less than 7 points in Apgar scores
5.	Newborns without antenatal risk factors	Newborns, whose mothers during pregnancy were sick
6.		Newborns with congenital malformations.

Figure 1. The division of patients into groups

Table 3. Complementation of the vaccination schedule in the study and control group, timing performance of vaccinations, and the validity of avoiding immunization

156 newborns	Study group n = 23	Control group n = 133
Vaccination Schedule Compliance p < 0,001	74% (n = 17)	100% (n = 133)
Avoiding Immunization p < 0,001	100% (n = 23)	14% (n = 19)
Justified Avoiding Immunization ns (p = 0,892)	4% (n = 1)	4% (n = 5)
Individual Vaccination Calendar p < 0,001; OR = 0,04 (CI 95,0% 0,01–0,23)	26% (n = 6)	2% (n = 2)
Vaccination Calendar of possible siblings p < 0,001	57% (n = 13)	100% (n = 133)

Table 4. The implementation of vaccination in the first year of life in both groups in compared with the current Polish Calendar of Vaccination

		First year of life
Vaccination Calendar		BCG	HBV	DTP	HiB	IPV
Control group (n = 133)	received	100%	100%	100%	100%	100%
	not received	0%	0%	0%	0%	0%
		p < 0,00001	p < 0,00001	p < 0,00001	p < 0,00001	p < 0,00001
Study group (n = 23)	received	48% (n = 11)	59% (n = 13)	61% (n = 14)	61% (n = 14)	61% (n = 14)
	not received	52% (n = 12)	41% (n = 9)	39% (n = 9)	39% (n = 9)	39% (n = 9)
		p = 0,00053 Rr2-23 = 0 Rr1-20 = 2,09 CI 1,36–3,20 Rr1-23 = 0,478 CI 0,312–0,733 Rr2-20 = 0	p = 0,00349 Rr1-22 = 0 Rr1-22 = 0,591 CI 0,417–0,837 Rr1-22 = 1,69 CI 1,20–2,40 Rr1-23 = 0

Table 5. Sources of information about vaccinations in both groups

Sourcesof information	Study group n = 23	Control group n = 133	Results
Medical staff	39% (n = 9)	72% (n = 96)	p = 0,002 OR = 4,06 (CI 95,0% 1,61–10,12)
Media	56% (n = 13)	18% (n = 24)	p < 0,001 OR = 0,17 (CI 95,0% 0,07–0,43)
Friedns	22% (n = 5)	5% (n = 7)	p = 0,006 OR = 0,20 (CI 95,0% 0,06–0,70)