Prevalence and genotype distribution of human papillomavirus among women with cervical lesions in Shenzhen city, China

Figures & data

Table 1. Distribution of human papillomavirus genotypes according to the final diagnoses among the 5,255 patients

Genotype	All cases(%)	Normal Cervix(%)	LSIL(%)	HSIL(%)	ICC(%)	Others(%)	χ2 value	p value
Number of cases	4318 (82.17)	320	104	55	35	4741	-	-
HPV-positive	937 (17.83)	50 (15.63)	61 (58.65)	44 (80.00)	31 (88.57)	751 (15.84)	396.810	0
Low-risk HPV
HPV6	64 (1.22)	1 (0.31)	2 (1.92)			61 (1.29)	2.855	0.452
HPV11	40 (0.76)		1 (0.96)		1 (2.86)	38 (0.80)	5.305	0.171
HPV42	5 (0.10)					5 (0.11)	3.640	1
HPV43	11 (0.21)		2 (1.92)			9 (0.19)	9.002	0.074
HPV44	19 (0.36)	2 (0.63)				17 (0.36)	1.690	0.673
CP8304	73 (1.39)	4 (1.25)	3 (2.88)	1 (1.82)		65 (1.37)	2.422	0.538
High-risk HPV
HPV16	143 (2.72)	3 (0.94)	21 (20.19)	27 (49.09)	21 (60.00)	71 (1.50)	318.072	0
HPV18	39 (0.74)		7 (6.73)	6 (10.91)	4 (11.43)	22 (0.46)	70.063	0
HPV31	19 (0.36)	3 (0.94)	2 (1.92)		1 (2.86)	13 (0.27)	13.862	0.007
HPV33	29 (0.55)	7 (2.19)	1 (0.96)			21 (0.44)	12.308	0.011
HPV35	10 (0.19)	2 (0.63)			1 (2.86)	7 (0.15)	10.726	0.034
HPV39	71 (1.35)	4 (1.25)	3 (2.88)	2 (3.64)		62 (1.31)	4.612	0.253
HPV45	20 (0.38)	3 (0.94)	2 (1.92)			15 (0.32)	8.756	0.063
HPV51	88 (1.67)	5 (1.56)	4 (3.85)	2 (3.64)		77 (1.62)	4.769	0.243
HPV52	248 (4.72)	13 (4.06)	18 (17.31)	8 (14.55)	5 (14.29)	204 (4.30)	40.142	0
HPV53	79 (1.50)	4 (1.25)	4 (3.85)	1 (1.82)		70 (1.48)	3.933	0.314
HPV56	32 (0.61)	2 (0.63)	2 (1.92)			28 (0.59)	3.286	0.380
HPV58	160 (3.04)	10 (3.13)	9 (8.65)	3 (5.45)	1 (2.86)	137 (2.89)	10.473	0.023
HPV59	26 (0.49)	1 (0.31)				25 (0.53)	0.262	1
HPV66	41 (0.78)	1 (0.31)	2 (1.92)			38 (0.80)	2.589	0.498
HPV68	36 (0.69)	2 (0.63)	1 (0.96)			33 (0.70)	0.615	0.818

HPV, human papillomavirus; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; ICC, invasive cervical carcinoma

Table 2. Single and multiple infection status in patients with HPV infection

HPV infection	N	%
Single infection	696	74.28
Single low-risk infection	114	12.17
Single high-risk infection	582	62.11
Multiple infection	241	25.72
Double infection	180	19.21
Triple infection	47	5.02
Quadruple or five infection	14	1.49

Figure 1. Distribution of the five most prevalent HPV genotypes according to diagnosis. HPV, human papillomavirus; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; ICC, invasive cervical carcinoma

Figure 2. Rate of total and high-risk HPV infection across all age groups among 5,255 gynecology outpatients in Shenzhen city, China. HPV, human papillomavirus