Advanced search
Publication Cover
Human Vaccines & Immunotherapeutics Volume 16, 2020 - Issue 12
Submit an article Journal homepage
4,357
Views
17
CrossRef citations to date
0
Altmetric
Mini Review

BCG vaccine: a hope to control COVID-19 pandemic amid crisis

Yashpal Singh Malika Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2832-4854View further author information
ORCID Icon,
Mohd Ikram Ansaria Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaView further author information
,
Balasubramanian Ganeshb Department of Health Research (DHR), Ministry of Health & Family Welfare, Government of India, Laboratory Division, ICMR-National Institute of Epidemiology, (Indian Council of Medical Research), Ayapakkam, Chennai-Tamil Nadu, IndiaView further author information
,
Shubhankar Sircara Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaView further author information
,
Sudipta Bhata Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaView further author information
,
Tripti Pandea Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaView further author information
,
OR Vinodhkumarc Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaORCID Iconhttps://orcid.org/0000-0002-7232-4122View further author information
ORCID Icon,
Prashant Kumard Amity Institute of Virology and Immunology, J-3 Block, Amity University, Noida, Uttar Pradesh, IndiaView further author information
,
Mohd Iqbal Yatooe Division of Veterinary Clinical Complex, Faculty of Veterinary Sciences and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, Jammu and Kashmir, IndiaORCID Iconhttps://orcid.org/0000-0002-4501-7354View further author information
ORCID Icon,
Ruchi Tiwarif Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, IndiaORCID Iconhttps://orcid.org/0000-0001-6897-3472View further author information
ORCID Icon,
Nadia Touilg Laboratoire De Recherche Et De Biosécurité, Hôpital Militaire D’instruction Med V De, Rabat, MoroccoView further author information
,
Shailesh Kumar Patelh Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaView further author information
,
Mamta Pathakh Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaView further author information
,
Khan Sharuni Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaORCID Iconhttps://orcid.org/0000-0003-1040-3746View further author information
ORCID Icon &
Kuldeep Dhamah Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, IndiaORCID Iconhttps://orcid.org/0000-0001-7469-4752View further author information
ORCID Icon show all
Pages 2954-2962 | Received 30 Apr 2020, Accepted 27 Aug 2020, Published online: 29 Sep 2020

Figures & data

Figure 1. Innate and adaptive immune response to a pathogen (Virus/Bacteria/Parasite)

(1) Recruitment of antigen presenting cell (APC) at the injection site. (2) Enhancement of antigen uptake. (3) Enhancement of Th2 response. (4) Enhancement of humoral immune response. (5) Improvement in inflammasomes of macrophages.
Figure 1. Innate and adaptive immune response to a pathogen (Virus/Bacteria/Parasite)

Figure 2. Schematic representation of BCG-triggered immune response in cell-mediated immunity

Activation of phagocytes and a new cytokine environment leads to differentiation of naïve CD4 + T cells into TH1 and/or TH2 cells, which direct the immune response toward cellular or humoral immunity, respectively. The therapeutic effect of BCG depends on proper induction of TH1 immune response. IL-10 inhibits TH1 immune response, whereas IFN-γ inhibits TH2 immune response. Blocking IL-10 or inducing IFN-γ can lead to TH1-dominated immunity, which is essential for BCG-mediated heterologous immunity.
Figure 2. Schematic representation of BCG-triggered immune response in cell-mediated immunity

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.