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Human Vaccines & Immunotherapeutics Volume 17, 2021 - Issue 4
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Research Paper

Modeling the epidemiological impact and cost-effectiveness of a combined schoolgirl HPV vaccination and cervical cancer screening program among Chinese women

Xiaomeng Maa China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Health Science Centre, Xi’an Jiao Tong University, Xi’an, China;b Institute of Health Policy Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, CanadaORCID Iconhttps://orcid.org/0000-0002-4165-3062View further author information
ORCID Icon,
Katherine Harripersaudc Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USAView further author information
,
Kumi Smithc Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USAView further author information
,
Christopher K. Fairleyd Melbourne Sexual Health Centre, Alfred Health, Carlton, Australia;e Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Clayton, AustraliaORCID Iconhttps://orcid.org/0000-0001-9081-1664View further author information
ORCID Icon,
Huachun Zouf School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, ChinaView further author information
,
Zhuoru Zoua China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Health Science Centre, Xi’an Jiao Tong University, Xi’an, ChinaORCID Iconhttps://orcid.org/0000-0001-8837-0900View further author information
ORCID Icon,
Yueyun Wangg Department of Maternal Care, Shenzhen Maternity and Child Health Hospitals, Shenzhen, Guangdong, ChinaView further author information
,
Guihua Zhuanga China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Health Science Centre, Xi’an Jiao Tong University, Xi’an, ChinaView further author information
&
Lei Zhanga China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Health Science Centre, Xi’an Jiao Tong University, Xi’an, China;d Melbourne Sexual Health Centre, Alfred Health, Carlton, Australia;e Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Clayton, AustraliaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2343-084XView further author information
ORCID Icon show all
Pages 1073-1082 | Received 27 Apr 2020, Accepted 26 Sep 2020, Published online: 03 Dec 2020

Figures & data

Figure 1. Model diagram

Figure 1. Model diagram

Figure 2. Temporal projection of the HPV epidemic among Chinese women aged >25, with (a–f) qHPV schoolgirls vaccination program only; (g–l) scale-up cervical cancer screening only, 2020–2069

Figure 2. Temporal projection of the HPV epidemic among Chinese women aged >25, with (a–f) qHPV schoolgirls vaccination program only; (g–l) scale-up cervical cancer screening only, 2020–2069

Figure 3. Two-dimensional cost-effectiveness plane demonstrating the distribution of 1,000 simulations for incremental cost and DALYs prevented under intervening strategies with different vaccine prices. (a–c): single intervention with qHPV at different price levels; (d)-(f) 50% vaccination with scale-up screening strategies; (g–i): 90% vaccination with scale-up screening strategies

Figure 3. Two-dimensional cost-effectiveness plane demonstrating the distribution of 1,000 simulations for incremental cost and DALYs prevented under intervening strategies with different vaccine prices. (a–c): single intervention with qHPV at different price levels; (d)-(f) 50% vaccination with scale-up screening strategies; (g–i): 90% vaccination with scale-up screening strategies

Table 1. Cost-effective analysis of qHPV vaccination and screening strategies with a 50-year forecast, 2020 – 2069

Supplemental material

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