Factors associated with parents’ willingness to enroll their children in trials for COVID-19 vaccination

Figures & data

Table 1. Factors associated with child participating in a COVID-19 vaccine trial. SD- Standard Deviation

	Will not have child participate (n = 2211)	Will have child participate (n = 497)	P value
Child’s Mean Age in months (SD)	7.36 (5.06)	8.33 (5.02)	<.001
Child’s Gender Female	1069 (48.5%)	241 (48.9%)	.903
Child has Chronic Illness	306 (14.0%)	70 (14.1%)	.994
Chronic Medication Use by Child	377 (17.3%)	89 (17.9%)	.767
Child Vaccinations Up to Date	1919 (87.4%)	467 (94.5%)	<.001
Who is completing the survey			<.001
Father	490 (22.2%)	160 (32.3%)
Mother	1662 (75.3%)	320 (64.6%)
Other*	55 (2.49%)	15 (3.03%)
Parent’s age in years (SD)	39.1 (7.71)	40.7 (8.16)	<.001
Parents with post-secondary education	1676 (77.4%)	374 (76.6%)	.757
Parent willing to participate themselves in the same trial	504 (23.1%)	442 (89.7%)	<.001
Mean score Likert scale – parents concerned their child has COVID-19	1.92 (2.88)	2.11 (2.97)	.192
Mean score Likert scale- parents concerned they are sick with COVID-19	1.84 (2.73)	2.05 (2.87)	.147

(*) Grandparents or siblings

Table 2. Level of concordance between parents’ participation and their willingness to enroll their children in a COVID-19 in a vaccination trial. Complete answers were received by 2679 parents on “vaccine trial” question, and 2673 on “RCT Vaccine trial” question RCT = Randomized Controlled Trial

VACCINE TRIAL (N)	Parent will participate themselves (946)	Parents will not participate (1733)
Parent will allow child to participate (493)	442 (89.7%)	51 (10.3%)
Parent will not allow child to participate (2186)	504 (23.1%)	1682 (76.9%)
RCT VACCINE TRIAL (50% chance of getting vaccine) (N)	Parent will participate Themselves (761)	Parents will not participate (1912)
Parent will allow child to participate (385)	366 (95.1)	19 (4.9)
Parent will not allow child to participate (2288)	395 (17.3)	1893 (82.7)

Table 3. Predictors of parents agreeing for their child to enroll in a COVID-19 vaccination trial identified by multivariate logistic regression analysis

Factor evaluated	Odds ratio	OR 95% CI	P value
Mean Child’s Age in months	1	(1–1.01)	.009
Gender – Male	0.985	(0.718–1.35)	.926
Child has a chronic illness	1.09	(0.682–1.72)	.719
Child is Up to Date with Vaccinations	2.67	(1.35–5.71)	.007
Mother completing the survey	0.677	(0.472–0.972)	.034
Mean Parent’s Age in years	0.986	(0.963–1.01)	.271
Parent Education high school or less	1.79	(1.18–2.74)	.007
Parent concerned the child has COVID	1.03	(0.974–1.1)	.27
Parent plan to enroll themselves in a similar trial	32.9	(21.9–51.2)	<.001