Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China

Figures & data

Table 1. Summarizes the proportion of protective antibody of pertussis, diphtheria and tetanus antibodies among subjects by age group, gender, and residence place group

	N	Anti-DT Protective%(>0.1 IU/ml) (95% CI)	Anti-TT Protective%(>0.1 IU/ml)(95% CI)	Anti-PT Protective%(>40 IU/ml) (95% CI)
Age
<3 m 3-<18 m 18 m-<3y 3-<6y 6-<18y 18-<40y 40-<50 50-<60 ≥60 χ^2 P	71 102 65 65 87 74 62 61 79	18.3(11.0–28.9) 76.5(67.4–83.7) 76.9(65.4–85.5) 75.4(63.7–84.2) 65.5(55.1–74.7) 39.2(28.9–50.6) 29.0(19.2–41.3) 36.1(25.2–48.6) 58.2(47.2–68.5) 118.173 <0.0001	8.5%(3.9–17.2) 86.3%(78.3–91.6) 90.8%(81.3–95.7) 76.9%(65.4–85.5) 71.3%(61.0–79.7) 28.4%(19.4–39.5) 8.1%(3.5–17.5) 8.2%(3.6–17.8) 8.9(4.4–17.1) 331.367 <0.0001	4.2(1.5–11.7) 2.9(1.0–8.3) 4.6(1.6–12.7) 3.1(0.9–10.5) 4.6(1.8–11.2) 5.4(2.1–13.1) 3.2(0.9–11.0) 6.6(2.6–15.7) 7.6(3.5–15.6) 3.485 0.9003
Gender
Male Female χ^2 P	379 287	48.0(43.0–53.1) 42.8(37.1–48.7) 3.918 0.0478	57.8(52.8–62.7) 50.0(44.2–55.8) 1.757 0.185	5.3(3.4–8.0) 4.0(2.2–7.0) 0.622 0.4304
Residence place
Urban Rural χ^2 P	273 393	48.3(42.5–54.3) 44.0(39.1–49.0) 3.194 0.0739	58.6(52.7–64.3) 51.6(46.6–56.5) 1.211 0.271	6.2(3.9–9.8) 3.7(2.2–6.0) 2.365 0.1241
Total	666	5.4(5.1–5.8)	4.5(4.2–4.9)	4.7(3.3–6.5)

Abbreviation: DT, diphtheria toxin; TT, tetanus toxin; PT, pertussis toxin; CI, confidence interval; IU, international unit; IgG, immunoglobulin G

Figure 1. The distribution of anti-DT IgG level in the sera of subjects among different age groups different color bar represent different antibody level

Figure 2. The distribution of anti-TT IgG level in the sera of subjects among different age groups, different color bar represent different antibody level

Figure 3. The distribution of anti-PT IgG level in the sera of subjects among different age groups, different color bar represent different antibody level