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Research Paper

Sequential administration of Prevnar 13™ and PNEUMOVAX™ 23 in healthy participants 50 years of age and older

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Pages 2678-2690 | Received 04 Nov 2020, Accepted 06 Feb 2021, Published online: 21 May 2021

Figures & data

Figure 1. Trial design

Figure 1. Trial design

Table 1. Participant demographics

Figure 2. Participant disposition. Group #1 = PCV13 -> PPSV23 -> Placebo. Group #2 = PCV13 -> Placebo -> PPSV23. PPSV23 = 23-valent pneumococcal polysaccharide vaccine. PCV13 = 13-valent pneumococcal conjugate vaccine

Figure 2. Participant disposition. Group #1 = PCV13 -> PPSV23 -> Placebo. Group #2 = PCV13 -> Placebo -> PPSV23. PPSV23 = 23-valent pneumococcal polysaccharide vaccine. PCV13 = 13-valent pneumococcal conjugate vaccine

Table 2. Summary of adverse events (AEs) occurring on Days 1–14 after any vaccination (all subjects as treated)

Table 3. Listing of most frequently reported adverse events (>5% in either group)

Table 4. Summary of OPA GMTs measured

Table 5. Analysis of postvaccination OPA GMTs to pneumococcal serotypes at week 12 (per protocol population)

Figure 3a. Summary of OPA GMTs measured at baseline, weeks 8, 12, 26, and 30 (per protocol population)

Figure 3a. Summary of OPA GMTs measured at baseline, weeks 8, 12, 26, and 30 (per protocol population)

Figure 3b. (Continued)

Figure 3b. (Continued)
Supplemental material

Supplemental Material

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