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Human Vaccines & Immunotherapeutics Volume 17, 2021 - Issue 8
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Commentary

Strategies to sensitize cancer cells to immunotherapy

Andrew Georgea Department of Chemistry, Brown University, Providence, RI, USA;b Department of Molecular Biology, Cell Biology & Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI, USA
,
Ilyas Sahinc Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI, USA;d Division of Hematology/Oncology, The Warren Alpert Medical School, Brown University, Providence, RI, USA
,
Benedito A. Carneiroc Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI, USA;d Division of Hematology/Oncology, The Warren Alpert Medical School, Brown University, Providence, RI, USA;e The Warren Alpert Medical School, Cancer Center at Brown University, Brown University, Providence, RI, USA
,
Don S. Dizonc Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI, USA;d Division of Hematology/Oncology, The Warren Alpert Medical School, Brown University, Providence, RI, USA;e The Warren Alpert Medical School, Cancer Center at Brown University, Brown University, Providence, RI, USA
,
Howard P. Safranc Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI, USA;d Division of Hematology/Oncology, The Warren Alpert Medical School, Brown University, Providence, RI, USA;e The Warren Alpert Medical School, Cancer Center at Brown University, Brown University, Providence, RI, USA
&
Wafik S. El-Deiryc Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI, USA;d Division of Hematology/Oncology, The Warren Alpert Medical School, Brown University, Providence, RI, USA;e The Warren Alpert Medical School, Cancer Center at Brown University, Brown University, Providence, RI, USA;f Department of Pathology & Laboratory Medicine, The Warren Alpert Medical School, Brown University, Providence, RI, USACorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-9577-8266
ORCID Icon
Pages 2595-2601 | Received 21 Jan 2021, Accepted 11 Feb 2021, Published online: 21 May 2021

Figures & data

Figure 1. Graphical summary of immunotherapeutic treatment strategies that target the tumor microenvironment. Offset (top left) depicts the interaction between a CD8 + T cell and both an APC and tumor cell without treatment. The main figure depicts various treatment strategies and their modulation of the tumor microenvironment. Various cytokines are also depicted in their most common and relevant roles within the tumor microenvironment

Figure 1. Graphical summary of immunotherapeutic treatment strategies that target the tumor microenvironment. Offset (top left) depicts the interaction between a CD8 + T cell and both an APC and tumor cell without treatment. The main figure depicts various treatment strategies and their modulation of the tumor microenvironment. Various cytokines are also depicted in their most common and relevant roles within the tumor microenvironment

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