Research trends in rabies vaccine in the last three decades: a bibliometric analysis of global perspective

Figures & data

Figure 1. Flow chart of included studies on rabies vaccine

Figure 2. Publication trends in rabies vaccine (1991-2020)

Table 1. Characteristic features of included studies on rabies vaccine

No.	Characteristic	Number of publications	% of 1,042
Top-10 most productive countries
1	United States of America	380	36.5
2	France	128	12.3
3	People’s Republic of China	97	9.3
4	India	89	8.5
5	Germany	75	7.2
6	England	63	6.1
7	Thailand	53	5.1
8	Canada	52	5
9	Brazil	45	4.3
10	Japan	38	3.7
Top-10 most studied Web of Science categories
1	Immunology	344	33.0
2	Veterinary Sciences	277	26.6
3	Medicine Research Experimental	255	24.5
4	Infectious Diseases	154	14.8
5	Virology	109	10.5
6	Biotechnology Applied Microbiology	87	8.4
7	Public Environmental Occupational Health	78	7.5
8	Tropical Medicine	63	6.1
9	Microbiology	52	5.0
10	Pharmacology Pharmacy	50	4.8
Top-10 most productive organizations
1	Centers for Disease Control and Prevention	80	7.7
2	Thomas Jefferson University	48	4.6
3	Institute Pasteur	44	4.2
4	Kansas State University	31	3.0
5	University of Georgia	31	3.0
6	United States Department of Agriculture	26	2.5
7	Friedrich Loeffler Institute	23	2.2
8	Academy of Military Medical Sciences	20	1.9
9	Canadian Food Inspection Agency	20	1.9
10	Chulalongkorn University	20	1.9
Top-10 funding sources
1	United States Department Of Health Human Services	82	7.9
2	National Institutes of Health	75	7.2
3	National Institute of Allergy Infectious Diseases	59	5.7
4	National Natural Science Foundation Of China	32	3.1
5	Wellcome Trust	17	1.6
6	National High Technology Research and Development Program of China	11	1.1
7	Sanofi Pasteur	11	1.1
8	Centers For Disease Control Prevention	9	0.9
9	Department for Environment Food Rural Affairs	9	0.9
10	Japan Society for the Promotion of Science	9	0.9
Top-10 most prolific authors
1	Rupprecht CE	55	5.3
2	Cliquet F	34	3.3
3	Muller T	31	3.0
4	Vos A	30	2.8
5	Schnell MJ	27	2.6
6	Fooks AR	24	2.3
7	Khawplod P	24	2.3
8	Wilde H	24	2.3
9	Slate D	22	2.1
10	Blanton JD	21	2.0

Table 2. Top-10 most attractive journals in rabies vaccine

Ranking	Journal name	Number of publications	% of 1,042	Impact factor^a
1	Vaccine	218	20.9	3.143
2	Journal of Wildlife Diseases	64	6.1	1.187
3	PLOS Neglected Tropical Diseases	31	3	3.885
4	Biologicals	26	2.5	1.801
5	Journal of Virology	20	1.9	4.501
6	Human Vaccines & Immunotherapeutics	19	1.8	2.619
7	Journal of Travel Medicine	19	1.8	7.089
8	Preventive Veterinary Medicine	16	1.5	2.304
9	Zoonoses and Public Health	16	1.5	2.271
10	Archives of Virology	15	1.4	2.243

^aImpact factor of the journals for the year 2019 published in 2020 (InCites Journal Citation Report, Clarivate Analytics).

Table 3. Top-10 most cited studies on rabies vaccine

No.	Title	Authors	Journal	Publication year	Total citations	Average citations per Year	Citation in 2020
1	Vaccination with a Plasmid Vector Carrying the Rabies Virus Glycoprotein Gene Induces Protective Immunity against Rabies Virus	Xiang et al.	Virology	1994	352	12.57	3
2	Large-Scale Eradication of Rabies using Recombinant Vaccinia-Rabies Vaccine	Brochier et al.	Nature	1991	210	6.77	5
3	Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine	Yusibov et al.	Vaccine	2002	178	8.9	8
4	Immune-Responses to Nucleic-Acid Vaccines to Rabies Virus	Xiang et al.	Virology	1995	157	5.81	0
5	A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries	Cleaveland, et al.	Vaccine	2003	148	7.79	11
6	Oral Rabies Vaccination in North America: Opportunities, Complexities, and Challenges	Slate et al.	PLOS Neglected Tropical Diseases	2009	146	11.23	11
7	Improved recovery of rabies virus from cloned cDNA using a vaccinia virus-free reverse genetics system	Ito et al.	Microbiology and Immunology	2003	117	6.16	10
8	Brief report: Human infection due to recombinant vaccinia-rabies glycoprotein virus	Rupprecht et al.	New England Journal of Medicine	2001	117	5.57	6
9	Canine rabies vaccination and domestic dog population characteristics in the developing world: A systematic review	Davlin & Vonville	Vaccine	2012	110	11	11
10	Rabies control in rural Africa: Evaluating strategies for effective domestic dog vaccination	Kaare et al.	Vaccine	2009	107	8.23	6

Figure 3. Minimum cluster size was fixed at 3. Four clusters are formed; red represents cluster 1 (n = 10 items), green represents cluster 2 (n = 7 items), blue represents cluster 3 (n = 5 items), and yellow represents cluster 4 (n = 4 items). (a) Network visualization of co-authorship countries (weights: documents). (b) Overlay visualization of co–authorship countries by time 1991-2020 (weights: documents, scores: average publications per year)

Figure 4. Minimum cluster size was fixed at 5, however six clusters are formed; red represents cluster 1 (n = 121 items), green represents cluster 2 (n = 109 items), blue represents cluster 3 (n = 95 items), yellow represents cluster 4 (n = 93 items), purple represent cluster 5 (n = 66 items), light–blue represents cluster 6 (n = 50 items), and orange represent cluster 7 (n = 5 items). (a) Network visualization of all keywords (wieghts: occurences). (b) Overlay visualization of all keywords by time 1991-2020 (wieghts: ocurrences, score: average publications per year)

Figure 5. Minimum cluster size was 5. However, seven clusters are formed; red represents cluster 1 (n = 27 items), green represents cluster 2 (n = 22 items), blue represents cluster 3 (n = 17 items), yellow represents cluster 4 (n = 16) items, purple represent cluster 5 (n = 16 items), light-blue represents cluster 6 (n = 14 items), and orange represents cluster 7 (n = 11 items). (a) Network visualization of authors citation (wieghts: citations). (b) Overlay visualization by citations (wieghts: citations, scores: citations, minimum score = 50, maximum = 100)