Evaluation of measles vaccination coverage in Lincang City, Yunnan Province, China

Figures & data

Table 1. Demographic characteristics of children

Characteristics	County								Total
	Cangyuan	Fengqing	Gengma	Linxiang	Shuangjiang	Yongde	Yunxian	Zhenkang
Sex
Male	80 (68.4)	59 (50.4)	52 (44.1)	58 (49.6)	61 (52.1)	50 (42.7)	53 (44.9)	59 (50.4)	472 (50.3)
Female	37 (31.6)	58 (49.6)	66 (55.9)	59 (50.4)	56 (47.9)	67 (57.3)	65 (55.1)	58 (49.6)	466 (49.7)
Ethnicity
Han	7 (6.0)	88 (75.2)	46 (39.0)	111 (94.9)	2 (1.7)	89 (76.1)	64 (54.2)	82 (70.1)	489 (52.1)
Yi	0 (0.0)	22 (18.8)	2 (1.7)	3 (2.6)	72 (61.5)	16 (13.7)	54 (45.8)	1 (0.9)	170 (18.1)
Other	110 (94.0)	7 (6.0)	70 (59.3)	3 (2.6)	43 (36.8)	12 (10.3)	0 (0.0)	34 (29.1)	279 (29.7)
Age, months
8–17	45 (38.5)	45 (38.5)	45 (38.1)	44 (37.6)	44 (37.6)	44 (37.6)	44 (37.3)	43 (36.8)	354 (37.8)
18–24	10 (8.5)	8 (6.8)	17 (14.4)	7 (6.0)	13 (11.1)	15 (12.8)	19 (16.1)	10 (8.5)	99 (10.6)
25–36	25 (21.4)	28 (23.9)	19 (16.1)	30 (25.6)	23 (19.7)	22 (18.8)	16 (13.6)	26 (22.2)	189 (20.1)
37–48	11 (9.4)	17 (14.5)	9 (7.6)	9 (7.7)	20 (17.1)	22 (18.8)	17 (14.4)	10 (8.5)	115 (12.3)
49–60	20 (17.1)	9 (7.7)	13 (11.0)	14 (12.0)	7 (6.0)	10 (8.5)	13 (11.0)	10 (8.5)	96 (10.2)
61–72	6 (5.1)	8 (6.8)	7 (5.9)	6 (5.1)	10 (8.5)	2 (1.7)	7 (5.9)	9 (7.7)	55 (5.9)
73–83	0 (0.0)	2 (1.7)	8 (6.8)	7 (6.0)	0 (0.0)	2 (1.7)	2 (1.7)	9 (7.7)	30 (3.2)
Total	117	117	118	117	117	117	118	117	938

Table 2. Number and coverage of vaccination for MCV1 and MCV2 by county

Vaccination status	Cangyuan (%)		Fengqing (%)		Gengma (%)		Linxiang (%)		Shuangjiang (%)		Yongde (%)		Yunxian (%)		Zhenkang (%)		Overall (%)
	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI
MCV1
Early	52 (44.4)	35.4–53.4	5 (4.3)	0.6–7.9	7 (5.9)	1.7–10.2	7 (6.0)	1.7–10.3	9 (7.7)	2.9–12.5	8 (6.8)	2.3–11.4	10 (8.5)	3.4–13.5	12 (10.3)	4.8–15.8	110 (11.7)	9.7–13.8
Timely	64 (54.7)	45.7–63.7	59 (50.4)	41.4–59.5	61 (51.7)	42.7–60.7	52 (44.4)	35.4–53.4	69 (59.0)	50.1–67.9	63 (53.8)	44.8–62.9	47 (39.8)	31–48.7	73 (62.4)	53.6–71.2	488 (52.0)	48.8–55.2
Delayed	1 (0.9)	0.0–2.5	53 (45.3)	36.3–54.3	50 (42.4)	33.5–51.3	57 (48.7)	39.7–57.8	39 (33.3)	24.8–41.9	46 (39.3)	30.5–48.2	56 (47.5)	38.4–56.5	28 (23.9)	16.2–31.7	330 (35.2)	32.1–38.2
Unvaccinated	0 (0.0)	0.0–0.0	0 (0.0)	0.0–0.0	0 (0.0)	0.0–0.0	1 (0.9)	0.0–2.5	0 (0.0)	0.0–0.0	0 (0.0)	0.0–0.0	5 (4.2)	0.6–7.9	4 (3.4)	0.1–6.7	10 (1.1)	0.4–1.7
MCV2
Early	4 (6.3)	0.3–12.2	7 (10.6)	0.4–12.1	5 (8.3)	0.1–12.4	1 (1.5)	0.5–0.5	3 (4.8)	0.3–12.2	6 (10.0)	0.1–12.4	9 (16.1)	0.0–12.6	6 (9.1)	0.4–12.1	41 (8.2)	4.1–8.4
Timely	55 (85.9)	77.4–94.5	45 (68.2)	77.6–94.3	47 (78.3)	77.1–94.7	45 (67.2)	77.6–77.6	49 (77.8)	77.4–94.5	48 (80.0)	77.1–94.7	30 (53.6)	76.8–95	53 (80.3)	77.6–94.3	372 (74.1)	82.9–89.0
Delayed	4 (6.3)	0.3–12.2	14 (21.2)	0.4–12.1	7 (11.7)	0.1–12.4	18 (26.9)	0.5–0.5	7 (11.1)	0.3–12.2	4 (6.7)	0.1–12.4	9 (16.1)	0.0–12.6	5 (7.6)	0.4–12.1	68 (13.5)	4.1–8.4
Unvaccinated	1 (1.6)	0.0–4.6	0 (0.0)	0.0–4.6	1 (1.7)	0.0–4.7	3 (4.5)	0.0–1.4	4 (6.3)	0.0–4.6	2 (3.3)	0.0–4.7	8 (14.3)	0.0–4.8	2 (3.0)	0.0–4.6	21 (4.2)	0.5–2.6
MCV1&MCV2
Complete	69 (61.1)	52.1–70.1	70 (59.8)	50.9–68.7	70 (59.3)	50.5–68.2	67 (57.3)	48.3–66.2	66 (56.4)	47.4–65.4	68 (59.1)	50.1–68.1	58 (49.2)	40.1–58.2	72 (61.5)	52.7–70.4	540 (57.9)	54.8–61.1
Timely-and–complete	26 (40.6)	28.6–52.7	28 (42.4)	30.5–54.3	28 (46.7)	34.0–59.3	23 (34.3)	23.0–45.7	29 (46.0)	33.7–58.3	24 (40.0)	27.6–52.4	13 (23.2)	12.2–34.3	35 (53.0)	41.0–65.1	206 (41.0)	36.7–45.3
One does or Unvaccinated	48 (41.0)	33.6–49.9	47 (40.2)	32.9–49.1	48 (40.7)	33.3–49.5	50 (42.7)	35.0–51.7	51 (43.6)	35.7–52.6	49 (41.9)	34.3–50.8	60 (50.8)	41.7–59.9	45 (38.5)	31.5–47.3	398 (42.4)	39.7–45.6

*A total of 502 children were included in the calculation of MCV2 vaccination coverage. Children under 24 months of age were excluded. A total of 932 children were included in the calculation of the complete vaccine coverage rate. Children under 8 months of age were excluded. A total of 502 children were included in the calculation of the timely-complete vaccination coverage. Children under 24 months of age were excluded.

MCV1, measles-containing vaccine first dose; MCV2, measles–containing vaccine second dose.

Table 3. Median delay vaccination period for MCV1 and MCV2

Surveyed county	MCV1		MCV2
	Median delay period, days	95%CI	Median delay period, days	95%CI
Cangyuan	149	149–149	275	0–646
Fengqing	27	16–38	177	10–344
Gengma	19	7–31	85	0–211
Linxiang	29	14–44	238	0–570
Shaungjiang	56	34–78	172	26–318
Yongde	48	21–75	183	13–353
Yunxian	37	23–51	308	110–506
Zhenkang	39	4–74	159	128–190
Overall	33	27–39	196	146–246

CI, confidence interval; MCV1, measles-containing vaccine first dose; MCV2, measles–containing vaccine second dose.

Figure 1. Kaplan-Meier curves of delayed vaccination for measles-containing vaccination 1 (MCV1, red) and measles-containing vaccination 2 (MCV2, blue) among children in Lincang City, Yunnan Province, China. The shaded areas represent the 95% confidence intervals. The dashed lines indicate that the median delay in vaccination is 33 days for MCV1, and 196 days for MCV2

Table 4. Seroepidemiological profiles by sex, ethnicity, age, county and vaccination status

Characteristics	Number	Seropositive (%)	95% CI	χ^2	P	GMT
Sex
Male	472	437 (92.6)	90.2–94.9	12.847	<0.001	1228.3
Female	466	455 (97.6)	96.3–99.0			1229.3
Ethnicity
Han	489	469 (95.9)	94.2–97.7	18.993	<0.001	1229.1
Yi	170	165 (97.1)	94.5–99.6			1207.0
Other	279	248 (88.9)	85.2–92.6			1157.1
Age, months
8–17	354	326 (92.1)	89.3–94.9	4.765	0.574	1128.3
18–24	99	95 (96.0)	92.1–99.8			1224.9
25–36	192	184 (95.8)	93.0–98.7			1230.2
37–48	112	105 (93.8)	89.3–98.2			1231.6
49–60	96	92 (95.8)	91.8–99.8			1231.3
61–72	55	52 (94.5)	88.5–100.0			1224.1
73–83	30	28 (93.3)	84.4–100.0			1230.4
County
Cangyuan	117	92 (78.6)	71.2–86.1	66.136	<0.001	478.7
Fengqing	117	110 (94.0)	89.7–98.3			843.8
Gengma	118	111 (94.1)	89.8–98.3			1462.6
Linxiang	117	108 (92.3)	87.5–97.1			1108.3
Shuangjiang	117	113 (96.6)	93.3–99.9			2298.2
Yongde	117	116 (99.1)	97.5–100.0			1182.5
Yunxian	118	116 (98.3)	96.0–100.0			1869.5
Zhenkang	117	116 (99.1)	97.5–100.0			1433.1
Vaccination status
Complete	540	513 (95.0)	93.2–96.8	5.322	0.126	1230.9
Timely–complete	206	196 (95.1)	92.2–98.1			1230.0
One does	388	361 (93.0)	90.5–95.6			1229.2
Unvaccinated	10	8 (80.0)	55.2–100.0			1225.3
Total	938	882 (94.0)	92.5–95.5	–	–	1210.1

CI, confidence interval; GMT, geometric mean titer.

Figure 2. The seropositivity rate and the geometric mean titer (GMT) of anti-measles IgG among children in Lincang City, Yunnan Province, China, according to county. The seropositivity rate by county is shown on the left, and the GMT by county is shown on the right