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Research Paper

Understanding confidence in the human papillomavirus vaccine in Japan: a web-based survey of mothers, female adolescents, and healthcare professionals

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Pages 3102-3112 | Received 22 Dec 2020, Accepted 12 Apr 2021, Published online: 01 Jun 2021

Figures & data

Table 1. Demographic and baseline characterstics of mothers (n=1646)

Table 2. Demographic and baseline characterstics of female adolescents (n=562)

Table 3. Demographic and baseline characterstics of HCPs (n=919)

Figure 1. Study flow diagram. Mothers who have ≥1 daughter aged 12–16 years and female adolescents aged 16–19 years were randomly sampled given the large number of such individuals registered in the database, but e-mail invitations were sent to all female adolescents aged 15 years who were registered in the database. Gynecologists/obstetricians, pediatricians, and internists were randomly sampled

*As reflected by answers of “Willing” or “Very willing.” **As reflected by an answer of “Do not know.” ***As reflected by answers of “Not willing” or “Very unwilling.”HCP = healthcare professional; HPV = human papillomavirus.
Figure 1. Study flow diagram. Mothers who have ≥1 daughter aged 12–16 years and female adolescents aged 16–19 years were randomly sampled given the large number of such individuals registered in the database, but e-mail invitations were sent to all female adolescents aged 15 years who were registered in the database. Gynecologists/obstetricians, pediatricians, and internists were randomly sampled

Figure 2. HPV vaccine confidence. HPV vaccine importance: “Overall, I think HPV vaccines are important to have”; HPV vaccine effectiveness: “Overall, I think HPV vaccines are effective”; HPV vaccine safety: “Overall, I think HPV vaccines are effective.” *Mothers who have daughters unvaccinated against HPV. **Female adolescents who never received the HPV vaccine. ***HCPs who do not currently recommend HPV vaccination to their patients. P<.001 for between-group comparison for the proportions of “Tend to agree” and “Strongly agree.”

HCP = healthcare professional; HPV = human papillomavirus.
Figure 2. HPV vaccine confidence. HPV vaccine importance: “Overall, I think HPV vaccines are important to have”; HPV vaccine effectiveness: “Overall, I think HPV vaccines are effective”; HPV vaccine safety: “Overall, I think HPV vaccines are effective.” *Mothers who have daughters unvaccinated against HPV. **Female adolescents who never received the HPV vaccine. ***HCPs who do not currently recommend HPV vaccination to their patients. P<.001 for between-group comparison for the proportions of “Tend to agree” and “Strongly agree.”

Figure 3. Awareness of cervical cancer and the HPV vaccine. *Mothers who have daughters unvaccinated against HPV. **Female adolescents who never received the HPV vaccine. ***HCPs who do not currently recommend HPV vaccination to their patients. P<.001 for between-group comparison for the proportions of “I know about it to some extent” and “I know about it in detail for both items.”

HCP = healthcare professional; HPV = human papillomavirus.
Figure 3. Awareness of cervical cancer and the HPV vaccine. *Mothers who have daughters unvaccinated against HPV. **Female adolescents who never received the HPV vaccine. ***HCPs who do not currently recommend HPV vaccination to their patients. P<.001 for between-group comparison for the proportions of “I know about it to some extent” and “I know about it in detail for both items.”

Figure 4. Willingness to receive or recommend the HPV vaccine. *Mothers who have daughters unvaccinated against HPV. **Female adolescents who never received the HPV vaccine. ***HCPs who do not currently recommend HPV vaccination to their patients. P<.001 for between-group comparison for the proportions of “Willing” to receive or recommend the HPV vaccine

HCP = healthcare professional; HPV = human papillomavirus.
Figure 4. Willingness to receive or recommend the HPV vaccine. *Mothers who have daughters unvaccinated against HPV. **Female adolescents who never received the HPV vaccine. ***HCPs who do not currently recommend HPV vaccination to their patients. P<.001 for between-group comparison for the proportions of “Willing” to receive or recommend the HPV vaccine

Figure 5. (a) Reasons for having received or to recommend the HPV vaccine (multiple answers allowed), and (b) reasons for not to decide to have received or not to decide to recommend the HPV vaccine (multiple answers allowed). Main reasons present only those items that had a response rate of 20% or more in at least one of the three groups. Please refer to supplementary tables for further details on all items

HCP = healthcare professional; HPV = human papillomavirus.
Figure 5. (a) Reasons for having received or to recommend the HPV vaccine (multiple answers allowed), and (b) reasons for not to decide to have received or not to decide to recommend the HPV vaccine (multiple answers allowed). Main reasons present only those items that had a response rate of 20% or more in at least one of the three groups. Please refer to supplementary tables for further details on all items

Figure 6. Sources of information used to decide whether (a) or not (b) to receive or recommend the HPV vaccine (multiple answers allowed). Main sources of information present only those items that had a response rate of 20% or more in at least one of the three groups. Please refer to supplementary tables for further details on all items

HCP = healthcare professional; HPV = human papillomavirus; MHLW = Ministry of Health, Labour and Welfare; TV = television.
Figure 6. Sources of information used to decide whether (a) or not (b) to receive or recommend the HPV vaccine (multiple answers allowed). Main sources of information present only those items that had a response rate of 20% or more in at least one of the three groups. Please refer to supplementary tables for further details on all items

Figure 7. Timing of recommendation for HCPs who currently recommend or who are willing to recommend the HPV vaccine (in response to the question, “When would you like to recommend HPV vaccines to your patients?”). When the HCPs who recommend HPV vaccines “Anytime even if patients would not ask me about HPV vaccines” and those who recommend “When patients ask me about the vaccines” were asked their reasons, there were differences of more than 15 points between these two groups with regard to “Safety (I think HPV vaccines are safe),” “Sufficient information (We know enough about HPV vaccines),” and “Routine vaccination (HPV vaccines are free for girls of an HPV vaccine–eligible age).”

HCP = healthcare professional; HPV = human papillomavirus; MHLW = Ministry of Health, Labour and Welfare.
Figure 7. Timing of recommendation for HCPs who currently recommend or who are willing to recommend the HPV vaccine (in response to the question, “When would you like to recommend HPV vaccines to your patients?”). When the HCPs who recommend HPV vaccines “Anytime even if patients would not ask me about HPV vaccines” and those who recommend “When patients ask me about the vaccines” were asked their reasons, there were differences of more than 15 points between these two groups with regard to “Safety (I think HPV vaccines are safe),” “Sufficient information (We know enough about HPV vaccines),” and “Routine vaccination (HPV vaccines are free for girls of an HPV vaccine–eligible age).”

Figure 8. Timing of HPV vaccination for mothers who are willing to have their daughters receive the HPV vaccine (when asked, “When would you like to have your daughter(s) receive HPV vaccines?”) and female adolescents who are willing to receive the HPV vaccine (when asked, “When would you like to receive the HPV vaccine?”)

HPV = human papillomavirus.
Figure 8. Timing of HPV vaccination for mothers who are willing to have their daughters receive the HPV vaccine (when asked, “When would you like to have your daughter(s) receive HPV vaccines?”) and female adolescents who are willing to receive the HPV vaccine (when asked, “When would you like to receive the HPV vaccine?”)
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