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Research Paper

Immunogenicity and safety levels of inactivated quadrivalent influenza vaccine in healthy adults via meta-analysis

, , , , , & show all
Pages 3652-3661 | Received 16 Feb 2021, Accepted 13 May 2021, Published online: 22 Jun 2021

Figures & data

Table 1. Characteristics of eligible trials

Figure 1. Diagram of risk of bias summary and bias graph for the 9 eligible studies

Figure 1. Diagram of risk of bias summary and bias graph for the 9 eligible studies

Figure 1. Continued

Figure 1. Continued

Figure 2. Flow diagram of study selection for the current meta-analysis

Figure 2. Flow diagram of study selection for the current meta-analysis

Figure 3. (a,b). Seroconversion rate (SCR) at day 21 post-vaccination, QIV versus TIV in adults between 18 and 64 years old (A strains). (SCR is defined as the percentage of participants with either a pre-vaccination HAI titer <10 and a post-vaccination HAI titer ≥40 or a pre-vaccination HI titer ≥10 and a ≥4-fold increase in HI titer after vaccination)

Figure 3. (a,b). Seroconversion rate (SCR) at day 21 post-vaccination, QIV versus TIV in adults between 18 and 64 years old (A strains). (SCR is defined as the percentage of participants with either a pre-vaccination HAI titer <10 and a post-vaccination HAI titer ≥40 or a pre-vaccination HI titer ≥10 and a ≥4-fold increase in HI titer after vaccination)

Figure 3. Continued

Figure 3. Continued

Figure 4. (a,b). Seroprotection rate (SPR) at day 21 post-vaccination, QIV versus TIV in adults under 65 years old. (SPR is defined as the percentage of participants with a HAI titres≥40)

Figure 4. (a,b). Seroprotection rate (SPR) at day 21 post-vaccination, QIV versus TIV in adults under 65 years old. (SPR is defined as the percentage of participants with a HAI titres≥40)

Figure 4. Continued

Figure 4. Continued

Figure 5. Local and systemic adverse events(AE) post vaccination, QIV versus pooled TIV (TIV groups combined TIV-B/Victoria & TIV-B/Yamagata)

Figure 5. Local and systemic adverse events(AE) post vaccination, QIV versus pooled TIV (TIV groups combined TIV-B/Victoria & TIV-B/Yamagata)
Supplemental material

Supplemental Material

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