Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains

Figures & data

Figure 1. (A) TGF-β, (B) IL-1β, (C) IL-6, (D) IL-17 and (E) IFN-γ levels (pg/mL, except C ng/mL) in healthy donors (n = 27) representing the baseline, uninfected cells, and the BCG Moreau (hatched), Pasteur, Danish, and Russia strains in 48 h in vitro infection of human mononuclear cells. Box and whiskers plot denote the median and the interquartile range cytokine values in each condition. *p ≤ .05; ***p ≤ .0005 compared with baseline, and ^##p ≤ .005 compared with BCG Russia, according to Dunn’s paired test.

Table 1. Spearman’s correlation analysis of associations between cytokine levels using the four different BCG strains

		BCG Danish		BCG Moreau		BCG Pasteur		BCG Russia
Cytokines		rho	p value	rho	p value	rho	P value	rho	p value
IL-6 vs.	IL-17	0.95	<0.001^a	0.45	0.018^a	0.92	<0.001^a	0.58	0.080
	IFN-y	0.97	<0.001^a	0.46	0.027^a	0.90	<0.001^a	0.73	0.045^a
IL-17 vs.	IFN-y	0.94	<0.001^a	0.55	0.005^a	0.90	<0.001^a	1.00	<0.001^a