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Research Paper

Long-term efficacy data for the recombinant zoster vaccine: impact on public health and cost effectiveness in Germany

Pages 5296-5303 | Received 03 Aug 2021, Accepted 01 Nov 2021, Published online: 14 Dec 2021

Figures & data

Figure 1. ZOE-LTFU clinical trial, recombinant zoster vaccine efficacy estimates (red and blue dots) and the corresponding estimates of vaccine efficacy and waning over time.

ZOE-LTFU: zoster long-term follow-up study; YOA: years of age.
Figure 1. ZOE-LTFU clinical trial, recombinant zoster vaccine efficacy estimates (red and blue dots) and the corresponding estimates of vaccine efficacy and waning over time.

Table 1. Public health impact of both RZV and ZVL under base-case assumptions of 40% coverage (RZV second dose compliance of 70%) over a lifetime horizon from the age of vaccination

Figure 2. Number of cases avoided with RZV from the year of vaccination over the remaining lifetime by age cohort.

Approximate cohort sizes: 13 million, 9.5 million and 13 million individuals in 50–59, 60–69, and ≥70 YOA, respectively. HZ: herpes zoster; PHN: postherpetic neuralgia; RZV: recombinant zoster vaccine; YOA: years of age. Complications: complications other than PHN.
Figure 2. Number of cases avoided with RZV from the year of vaccination over the remaining lifetime by age cohort.

Figure 3. RZV vaccine efficacy estimates with associated annual wanings, public health impact in the German population and cost-effectiveness.

*A fixed cohort of a total of 1 M subjects at each age is assumed, of which 40% were assumed to be vaccinated with the first dose and 70% would receive a second dose of RZV. HZ: herpes zoster; K: thousands; M: million; PHN: postherpetic neuralgia; QALY: quality adjusted life-years, RZV: recombinant zoster vaccine; YOA: years of age.
Figure 3. RZV vaccine efficacy estimates with associated annual wanings, public health impact in the German population and cost-effectiveness.

Table 2. Number needed to vaccinate to prevent one HZ case and one PHN case under base-case assumptions of 40% coverage (RZV second dose compliance of 70%) over a lifetime horizon from the age of vaccination

Table 3. Cost-effectiveness of RZV vs no vaccination for various vaccination starting ages: assuming a fixed cohort of 1 million with a vaccine coverage of 40%

Table 4. Cost-effectiveness of RZV vs no vaccination for various age cohorts

Supplemental material

Supplemental Material

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