Prevalence and genotype distribution of human papillomavirus infection among women aged 30–65 years in Xi’an, China: a population-based study of 14,655 women

Figures & data

Table 1. Prevalence of human papillomavirus infection in women in Xi’an, China according to district (p = .013)

HPV types	Lianhu		Yanta		Baqiao		Changan		Weiyang		Beilin		Unknown
	n = 3082		n = 3187		n = 2683		n = 2821		n = 296		n = 238		n = 2348
	Single	Multiple**	Single	Multiple	Single	Multiple	Single	Multiple	Single	Multiple	Single	Multiple	Single	Multiple
HR-HPV types only	241	45	244	41	218	46	260	44	23	7	18	5	223	59
	(7.8%)	(1.5%)	(7.7%)	(1.3%)	(8.1%)	(1.7%)	(9.2%)	(1.6%)	(7.8%)	(2.4%)	(7.6%)	(2.1%)	(9.5%)	(2.5%)
LR-HPV types only	46	4	68	5	50	3	64	5	9	0	14	2	50	4
	(1.5%)	(0.1%)	(2.1%)	(0.2%)	(1.9%)	(0.1%)	(2.3%)	(0.2%)	(3.0%)	0	(5.9%)	(0.8%)	(2.1%)	(0.2%)
Mixed HR and LR HPV types	23*	8	27	20	15	14	20	14	4	0	3	1	18	20
	(0.7%)	(0.3%)	(0.8%)	(0.6%)	(0.6%)	(0.5%)	(0.7%)	(0.5%)	(1.4%)	0	(1.3%)	(0.4%)	(0.8%)	(0.9%)
Total	310	57	339	66	283	63	344	63	36	7	35	8	291	83
	(10.1%)	(1.8%)	(10.6%)	(2.1%)	(10.5%)	(2.3%)	(12.2%)	(2.2%)	(12.2%)	(2.4%)	(14.7%)	(3.4%)	(12.4%)	(3.5%)

*indicating single HR-HPV and single LR-HPV mixed infection.

**indicating HR-HPV types only: two and more HR-HPV types infections; LR-HPV types only: two and more LR-HPV types infections; Mixed HR and LR HPV types: two or more HR-HPV types and two or more LR-HPV types mixed infection.

Table 2. Prevalence of human papillomavirus infection in women in Xi’an, China according to age (p < .001)

HPV Types	30–34y		35–39y		40–44y		45–49y		50–54y		55–59y		≥60y
	n = 2537		n = 2680		n = 2599		n = 2510		n = 1982		n = 1605		n = 742
	Single	Multiple**	Single	Multiple	Single	Multiple	Single	Multiple	Single	Multiple	Single	Multiple	Single	Multiple
HR-HPV types only	209	37	196	31	189	35	232	33	167	38	157	49	77	24
	(8.2%)^a	(1.5%)^c	(7.3%)	(1.2%)	(7.3%)	(1.3%)	(9.2%)	(1.3%)	(8.4%)	(1.9%)	(9.8%)	(3.1%)	(10.4%)	(3.2%)
LR-HPV types only	32	5	57	4	48	3	60	2	55	3	35	6	14	0
	(1.3%)^b	(0.2%)	(2.1%)	(0.1%)	(1.8%)	(0.1%)	(2.4%)	(0.1%)	(2.8%)	(0.2%)	(2.2%)	(0.4%)	(1.9%)	0
Mixed HR and LR HPV types	18*	10	16	7	11	12	24	9	16	13	13	14	12	12
	(0.7%)	(0.4%)^d	(0.6%)	(0.3%)	(0.4%)	(0.5%)	(1.0%)	(0.4%)	(0.8%)	(0.7%)	(0.8)	(0.9%)	(1.6%)	(1.6%)
Total	259	52	269	42	248	50	316	44	238	54	205	69	103	36
	(10.2%)	(2.0%)	(10.0%)	(1.6%)	(9.5%)	(1.9%)	(12.6%)	(1.8%)	(12.0%)	(2.7%)	(12.8%)	(4.3%)	(13.9%)	(4.9%)

*indicating single HR-HPV and single LR-HPV mixed infection.

**indicating HR-HPV types only: two and more HR-HPV types infections; LR-HPV types only: two and more LR-HPV types infections; Mixed HR and LR HPV types: two or more HR-HPV types and two or more LR-HPV types mixed infection.

^aThe prevalence of single HR-HPV infection differed by age (P = .005).

^bThe prevalence of single LR-HPV infection differed by age (P = .018).

^cThe prevalence of multiple HR-HPV infections differed by age (P < .001).

^dThe prevalence of mixed HR-HPV and LR-HPV infections differed by age (P < .001).

Table 3. Distribution of single and multiple human papillomavirus infections in women in Xi’an, China

HPV infections	Positive case	Percentage (x/1985)	Prevalence (x/14655)
Single type	1528	77.0%	10.4%
Two types	320	16.1%	2.2%
Three types	104	5.2%	0.7%
Four types	26	1.3%	0.2%
≥Five types	7	0.4%	0%
Total	1985	100%	13.5%

Table 4. Prevalence of human papillomavirus in women in Xi’an, China according to genotype and district

Overall prevalence			Prevalence by different districts of Xi’an
	All population	Lianhu	Yanta	Baqiao	Changan	Weiyang	Beilin	Unknown
	n = 14655	n = 3082	n = 3187	n = 2683	n = 2821	n = 296	n = 238	n = 2348
HPV subtype	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n(%)
16	278 (1.9)	59 (1.9)	52 (1.6)	39 (1.5)	58 (2.1)	4 (1.4)	7 (2.9)	59 (2.5)
18	99 (0.7)	16 (0.5)	18 (0.6)	14 (0.5)	28 (1.0)	0 (0)	1 (0.4)	22 (0.9)
31	66 (0.5)	14 (0.5)	10 (0.3)	9 (0.3)	16 (0.6)	2 (0.7)	0 (0)	15 (0.6)
33	76 (0.5)	15 (0.5)	14 (0.4)	17 (0.6)	13 (0.5)	1 (0.3)	2 (0.8)	14 (0.6)
35	38 (0.3)	6 (0.2)	8 (0.3)	6 (0.2)	12 (0.4)	0 (0)	0 (0)	6 (0.3)
39	71 (0.5)	13 (0.4)	18 (0.6)	11 (0.4)	14 (0.5)	1 (0.3)	1 (0.4)	13 (0.6)
45	29 (0.2)	5 (0.2)	8 (0.3)	5 (0.2)	6 (0.2)	0 (0)	1 (0.4)	4 (0.2)
51	136 (0.9)	19 (0.6)	25 (0.8)	22 (0.8)	25 (0.9)	3 (1.0)	4 (1.7)	38 (1.6)
52	374 (2.6)	77 (2.5)	81 (2.5)	63 (2.3)	68 (2.4)	8 (2.7)	3 (1.3)	74 (3.2)
56	136 (0.9)	18 (0.6)	31 (1.0)	34 (1.3)	26 (0.9)	1 (0.3)	2 (0.8)	24 (1.0)
58	200 (1.4)	26 (0.8)	39 (1.2)	36 (1.3)	44 (1.6)	7 (2.4)	3 (1.3)	45 (1.9)
59	70 (0.5)	10 (0.3)	11 (0.3)	10 (0.4)	14 (0.5)	4 (1.4)	1 (0.4)	20 (0.9)
66	106 (0.7)	22 (0.7)	20 (0.6)	28 (1.0)	17 (0.6)	3 (1.0)	3 (1.3)	13 (0.6)
68	85 (0.6.)	17 (0.6)	13 (0.4)	15 (0.6)	17 (0.6)	1 (0.3)	5 (2.1)	17 (0.7)
82	17 (0.1)	4 (0.1)	2 (0.1)	2 (0.1)	1 (0)	1 (0.3)	0 (0)	7 (0.3)
26	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
53	258 (1.8)	53 (1.7)	54 (1.7)	49 (1.8)	54 (1.9)	6 (2.0)	5 (2.1)	37 (1.6)
73	15 (0.1)	2 (0.1)	2 (0.1)	2 (0.1)	4 (0.1)	1 (0.3)	0 (0)	4 (0.2)
6	39 (0.3)	5 (0.2)	7 (0.2)	6 (0.2)	11 (0.4)	1 (0.3)	0 (0)	9 (0.4)
11	11 (0.1)	0 (0)	3 (0.1)	2 (0.1)	4 (0.1)	0 (0)	1 (0.4)	1 (0)
40	28 (0.2)	6 (0.2)	10 (0.3)	2 (0.1)	8 (0.3)	0 (0)	0 (0)	2 (0.1)
42	155 (1.1)	23 (0.7)	29 (0.9)	25 (0.9)	35 (1.2)	2 (0.7)	9 (3.8)	32 (1.4)
43	99 (0.7)	16 (0.5)	20 (0.6)	12 (0.4)	21 (0.7)	3 (1.0)	2 (0.8)	25 (1.1)
44	54 (0.4)	10 (0.3)	22 (0.7)	12 (0.4)	4 (0.1)	0 (0)	0 (0)	6 (0.3)
54	98 (0.7)	16 (0.5)	38 (1.2)	24 (0.9)	12 (0.4)	0 (0)	0 (0)	8 (0.3)
61	94 (0.6)	26 (0.8)	28 (0.9)	14 (0.5)	18 (0.6)	0 (0)	0 (0)	8 (0.3)
81	120 (0.8)	14 (0.5)	23 (0.7)	15 (0.6)	24 (0.9)	7 (2.4)	8 (3.4)	29 (1.2)
83	11 (0.1)	1 (0)	4 (0.1)	3 (0.1)	1 (0)	0 (0)	2 (0.8)	0 (0)

Table 5. Prevalence of human papillomavirus infection in women in Xi’an, China according to genotype and age group

	Prevalence by age group
	30–34y	35–39y	40–44y	45–49y	50–54y	55–59y	≥60y
	n = 2537	n = 2680	n = 2599	n = 2510	n = 1982	n = 1605	n = 742
HPV subtype	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n (%)	Positive, n (%)
16	61 (2.4)	41 (1.5)	39 (1.5)	43 (1.7)	39 (2.0)	31 (1.9)	24 (3.2)
18	19 (0.7)	13 (0.5)	11 (0.4)	21 (0.8)	17 (0.9)	12 (0.7)	6 (0.8)
31	6 (0.2)	12 (0.4)	12 (0.5)	9 (0.4)	17 (0.9)	4 (0.2)	6 (0.8)
33	9 (0.4)	10 (0.4)	7 (0.3)	13 (0.5)	14 (0.7)	14 (0.9)	9 (1.2)
35	3 (0.1)	3 (0.1)	7 (0.3)	9 (0.4)	4 (0.2)	9 (0.6)	3 (0.4)
39	12 (0.5)	15 (0.6)	14 (0.5)	13 (0.5)	5 (0.3)	6 (0.4)	6 (0.8)
45	2 (0.1)	4 (0.1)	3 (0.1)	3 (0.1)	5 (0.3)	8 (0.5)	4 (0.5)
51	28 (1.1)	15 (0.6)	17 (0.7)	23 (0.9)	20 (1.0)	23 (1.4)	10 (1.3)
52	58 (2.3)	55 (2.1)	44 (1.7)	73 (2.9)	49 (2.5)	56 (3.5)	39 (5.3)
56	17 (0.7)	19 (0.7)	22 (0.8)	21 (0.8)	15 (0.8)	28 (1.7)	14 (1.9)
58	25 (1.0)	31 (1.2)	30 (1.2)	28 (1.1)	32 (1.6)	38 (2.4)	16 (2.2)
59	11 (0.4)	11 (0.4)	10 (0.4)	16 (0.6)	10 (0.5)	10 (0.6)	2 (0.3)
66	25 (1.0)	15 (0.6)	14 (0.5)	17 (0.7)	16 (0.8)	15 (0.9)	4 (0.5)
68	19 (0.7)	13 (0.5)	17 (0.7)	10 (0.4)	12 (0.6)	11 (0.7)	3 (0.4)
82	1 (0)	5 (0.2)	7 (0.3)	1 (0)	2 (0.1)	0 (0)	1 (0.1)
26	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
53	31 (1.2)	27 (1.0)	45 (1.7)	45 (1.8)	32 (1.6)	43 (2.7)	35 (4.7)
73	0 (0)	3 (0.1)	1 (0)	4 (0.2)	5 (0.3)	2 (0.1)	0 (0)
6	6 (0.2)	5 (0.2)	6 (0.2)	9 (0.4)	7 (0.4)	3 (0.2)	3 (0.4)
11	3 (0.1)	1 (0)	2 (0.1)	3 (0.1)	1 (0.1)	1 (0.1)	0 (0)
40	4 (0.2)	4 (0.1)	4 (0.2)	8 (0.3)	2 (0.1)	6 (0.4)	0 (0)
42	16 (0.6)	23 (0.9)	26 (1.0)	31 (1.2)	23 (1.2)	23 (1.4)	13 (1.8)
43	15 (0.6)	21 (0.8)	15 (0.6)	14 (0.6)	18 (0.9)	11 (0.7)	5 (0.7)
44	10 (0.4)	8 (0.3)	12 (0.5)	8 (0.3)	6 (0.3)	6 (0.4)	4 (0.5)
54	16 (0.6)	18 (0.7)	12 (0.5)	14 (0.6)	14 (0.7)	20 (1.2)	4 (0.5)
61	14 (0.6)	16 (0.6)	14 (0.5)	6 (0.2)	16 (0.8)	20 (1.2)	8 (1.1)
81	14 (0.6)	18 (0.7)	13 (0.5)	23 (0.9)	24 (1.2)	16 (1.0)	12 (1.6)
83	0 (0)	1 (0)	1 (0)	5 (0.2)	1 (0.1)	2 (0.1)	1 (0.1)