COVID-19 mRNA vaccine may trigger subacute thyroiditis

Figures & data

Table 1. Laboratory test results of cases after vaccination

	First case	Second case	Third case	Fourth case	Fifth case
Initial symptom	Neck pain, fatigue, palpitation	Neck pain, palpitation, sweating	Neck pain, nervousness, fatigue	Neck pain	Neck pain, headache, palpitation, sweating and tremor
Post-vaccination symptom onset time	8th day	6th day	4th day	6th day	9th day
TSH (0.27–4.2 mIU/L)	0.01	0.18	1.1	0.01	0.24
fT4 (0.93–1.7 ng/dL)	3.18	1.58	1.55	2.02	1.58
fT3 (2–4.4 ng/dL)	9.35	3.77	3.78	4.6	4.32
ESR (<20 mm/h)	32	80	28	34	44
CRP (0–5 mg/L)	124	34	15	27	18

TSH: Thyroid stimulating hormone, fT4: Free T4, fT3: Free T3, ESR: Erythrocyte sedimentation rate, CRP: C-reactive protein.

Figure 1. Thyroid ultrasonography of the cases. (a, b) First case. (a) Right lobe and (b) left lobe. (c, d) Second case. (a) Right lobe and (b) left lobe. (e, f) Third case. (e) Axial resolution and (f) longitudinal resolution of the left lobe. (g, h) Fourth case: (g) thyroid ultrasonography of the left lobe and (h) thyroid scintigraphy imaging. (i, j) Fifth case. (i) Right lobe and (j) left lobe.

Figure 2. Follow-up laboratory results of the first case.

Figure 3. Follow-up laboratory results of the second case.

Table

SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2
fT4	Free thyroxine
fT3	Free triiodothyronine
TSH	Thyroid stimulating hormone
ACE2	Angiotensin converting enzyme 2
TMPRSS2	Transmembrane protease serine 2

Data availability statement

The datasets used are available from the corresponding author on reasonable request.