Modeling long-term persistence after 8 years of hepatitis B booster vaccination in 5- to 15-year-old children

Figures & data

Table 1. The basic information of participants (n,%).

	Total	Schedule 1	Schedule 2
Age (year)	7.7 ± 2.3	7.2 ± 2.2	7.9 ± 2.4
Sex
Male	196(45.5)	77(44.8)	119(45.9)
Female	235(54.5)	95(55.2)	140(54.1)
Vaccine
5 μg	110(25.5)	57(33.1)	53(20.5)
10 μg	119(27.6)	23(13.4)	96(37.0)
20 μg	94(21.8)	56(32.5)	38(14.7)
HAB	108(25.1)	36(20.9)	72(27.8)

Table 2. Distribution of gender at five follow-up time points (n, %).

Time (months)	male	female	χ2	P
1	192(98.0)	225(95.7)	1.04	31
7	196(100)	234(99.6)	<.001	1.00
18	191(97.5)	232(98.7)	0.38	54
66	175(89.3)	198(84.3)	1.91	17
102	154(78.6)	171(72.8)	1.64	20

Table 3. Anti-Hbs levels during follow-up period.

Time (months)	Anti-HBs levels (mIU/mL)
Total
1	1385.3(1138.1–1686.3)
7	954.6(836.2–1089.7)
18	675.1(534.1–853.2)
66	62.9(53.2–74.3)
102	33.8(28.1–40.7)
Schedule 1
1	4275.2(3560.3–5133.7)
7	880.7(698.2–1110.9)
18	1475.4(1076.9–2021.3)
66	140.6(109.2–181.0)
102	73.7(56.7–95.8)
Schedule 2
1	655.4(501.3–856.9)
7	1007.0(859.5–1179.8)
18	401.6(293.2–550.2)
66	36.9(30.3–44.9)
102	20.2(15.9–25.5)

Table 4. Mann-Kendall Test Results for anti-HBs levels at five time points.

	Total	Schedule 1	Schedule 2
Z	−27.7	−18.0	−21.6
P	<.001	<.001	<.001
S	−9.2 × 10^5	−1.5 × 10^5	−3.4 × 10^5
varS	1.1 × 10^9	7.1 × 10^7	2.4 × 10^8
tau	−.4	−40.4	0.4

Figure 1. Observed individual profiles (gray lines) and population-averaged estimation of Anti-HBs levels (blue and red line).

Table 5. Table parameter estimates and standard errors of the model.

Predictors	Estimates	Std. error	P
(Intercept)	8.8	0.3	<.001
Schedule	−1.0	0.2	<.001
Time2	−0.0	0.0	<.001
Schedule * time2	−0.0	0.0	05
Random Effects
σ^2	2.2
τ00 id	1.5
ICC	0.4
N id	431
Observations	2155
Marginal R^2 /Conditional R^2	0.4/.7

Table 6. Predicted proportion of participants whose anti-HBs ≥10 mIu/ml.

Time (months)	Seropositivity (n,%)
	Total	Schedule 1	Schedule 2
1	417(96.8)	172(100)	245(94.6)
7	430(99.8)	171(99.4)	259(100)
18	423(98.1)	171(99.4)	252(97.3)
66	373(86.5)	163(94.8)	210(81.1)
102	325(75.4)	154(89.5)	171(66.0)
120	430(99.8)	172(100)	258(99.6)
240	429(99.5)	172(100)	256(98.8)
360	331(76.8)	171(99.4)	162(62.5)