https://orcid.org/0000-0002-1794-9736
Figures & data
Figure 1. Results of SARS-CoV-2 S-IgG antibody titers in BNT162b2 vaccine recipients.
Boxes span the IQR. The line within each box denotes the median and the whiskers indicate 1.5 times IQR. P values were determined by Wilcoxon paired signed-rank test to compare different vaccination dose. S-IgG titer was log-transformed for analysis.
S-IgG: spike (S) immunoglobulin; IQR: interquartile range; BAU: binding antibody units.
*: p < 0.0001, **: p =0.0145
Figure 2. Correlation between spike glycoprotein IgG titers and neutralizing antibody titers against KUH003 (a), Alpha (b), and Delta (c).
P values were determined by Spearman’s correlation coefficient. S-IgG titers were correlated with neutralizing antibody titers against KUH003, Alpha, and Delta.
S-IgG: spike (S) immunoglobulin, BAU: binding antibody units.
Figure 3. Antibody responses elicited by the BNT162b2 vaccine. Neutralizing antibodies titers against KUH003, Alpha, and Delta were examined in participants vaccinated with one or two doses of BNT162b2.
*: p < 0.0001
The significance was assessed by one-way analysis of variance (ANOVA) corrected for multiple comparisons using Tukey’s method. Boxes represent variables’ distribution with quartiles and outliers. Horizontal bars have a mean median value.
Figure 4. Correlation between age and SARS-CoV-2 S-IgG antibody titers (a), neutralizing antibody titers against KHU003 (b), Alpha (c), and Delta (d).
White circles indicate antibody titers after the first vaccination. Black circles indicate antibody titers after the second vaccination. Age and S-IgG titer or neutralizing antibody titer against variants were correlated using Spearman’s correlation analysis. S-IgG titer was log-transformed for analysis. Negative correlations were demonstrated between age and S-IgG titers (r = −0.311) and neutralizing antibody titers against KUH003 (r = −0.332).
S-IgG: Spike (S) immunoglobulin, BAU: binding antibody units.
Table 1. The S-IgG titer and the neutralizing antibody titer of KUH003, alpha variant, and delta variant after BNT162b2 vaccination.