Evaluation of antibody response to SARS-CoV-2 variants after 2 doses of mRNA COVID-19 vaccine in a correctional facility

Figures & data

Figure 1. Virus neutralization (VN) titers to SARS-CoV-2 virus after 2 doses of mRNA vaccine in correctional officers and inmates. Panel a: VN titers against Wuhan strain in correctional officers; Panel b: VN titers against Wuhan strain in inmates; Panel c: VN titers against Wuhan and Alpha, Beta, Gamma, and Omicron BA.1 variants in correctional officers; Panel d: VN titers against Wuhan and Alpha, Beta, Gamma, and Omicron BA.1 variants in inmates. Dot plots show individual values. Tukey boxplots show outlier values (dots), medians (middle line), third and first quartiles (boxes), while the whiskers display the minimum and maximum values. Horizontal dashed line represents the Lower Limit of Quantification (LLOQ) of VN assay. Statistically significant differences were analyzed by Friedman and Dunn’s multiple comparisons test (p < .05).

Table 1. Fold decrease in virus neutralization titers to SARS-CoV-2 variants with respect to Wuhan strain in correctional officers, by variant.

Correctional officers
Variant	Alpha		Beta		Gamma		Omicron BA.1
Decrease	N	%	N	%	N	%	N	%
-	83	56.5	13	8.8	83	56.5	9	6.1
2-fold	40	27.2	45	30.6	48	32.6	17	11.6
4-fold	21	14.3	53	36.1	15	10.2	44	29.9
>4-fold	3	2.0	36	24.5	1	0.7	77	52.4
From 2 to >4-fold	64	43.5	134	91.2	64	43.5	138	93.9
Total	147	100.0	147	100.0	147	100.0	147	100.0

Table 2. Fold decrease in virus neutralization titers to SARS-CoV-2 variants with respect to Wuhan strain in inmates, by variant.

Inmates
Variant	Alpha		Beta		Gamma		Omicron BA.1
Decrease	N	%	N	%	N	%	N	%
-	102	52.3	29	14.9	124	63.6	14	7.2
2-fold	63	32.3	67	34.3	57	29.2	44	22.6
4-fold	27	13.9	63	32.3	11	5.7	51	26.1
>4-fold	3	1.5	36	18.5	3	1.5	86	44.1
From 2 to >4-fold	93	47.7	166	85.1	71	36.4	181	92.8
Total	195	100.0	195	100.0	195	100.0	195	100.0

Figure 2. Virus neutralization (VN) titers to SARS-CoV-2 virus after 2 doses of mRNA vaccine in nucleoprotein (NP) positive and NP negative subjects. Panel a: VN titers against Wuhan strain in NP positive subjects; Panel b: VN titers against Wuhan strain in NP negative subjects; Panel c: VN titers against Wuhan and Alpha, Beta, Gamma, and Omicron BA.1 variants in NP positive subjects; Panel d: VN titers against Wuhan and Alpha, Beta, Gamma, and Omicron BA.1 variants in NP negative subjects. Dot plots show individual values. Tukey boxplots show outlier values (dots), medians (middle line), third and first quartiles (boxes), while the whiskers display the minimum and maximum values. Horizontal dashed line represents the Lower Limit of Quantification (LLOQ) of VN assay. Statistically significant differences were analyzed by Friedman and Dunn’s multiple comparisons test (p < .05).