HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

Figures & data

Table 1. Age-stratified HPV prevalence in 21, 862 tested women.

Age Group,y	Total No.	lrHPV-only		hrHPV-only*		Mixed lrHPVand hrHPV		Total
		Positive No.	Positive, % (95%CI)	Positive No.	Positive, % (95%CI)	Positive No.	Positive, % (95%CI)	Positive No.	Positive, % (95%CI)
≤25**	1489	51	3.4(2.5–4.3)	223	15.0(13.2–16.8)	59	4.0 (3.0–5.0)	333	22.4(20.2–24.5)
26–35	6867	178	2.6(2.2–3.0)	756	11.0(10.3–11.7)	82	1.2(0.9–1.5)	1016	14.8(14.0–15.6)
36–45	7162	175	2.4(2.1–2.8)	827	11.5(10.8–12.3)	87	1.2(1.0–1.5)	1089	15.2(14.4–16.0)
46–55	4694	123	2.6(2.2–3.1)	584	12.4(11.5–13.4)	101	2.2(1.7–2.6)	808	17.2(16.1–18.3)
>55***	1650	59	3.6(2.7–4.5)	236	14.3(12.6–16.0)	50	3.0(2.2–3.9)	345	20.9(18.9–22.9)
Total	21862	586	2.7(2.5–2.9)	2626	12.0(11.6–12.4)	379	1.7(1.6–1.9)	3591	16.4(15.9–16.9)

*: HR-HPV infection rate was significantly higher than LR-HPV infection rate, P < 2.2e-16.

**: The infection rate in the ≤25 age group was significantly higher than the total infection rate, P = 1.886e-10.

***: The infection rate in the >55 age group was significantly higher than the total infection rate, P = 3.827e-7.

Figure 1. Infection rate of lrHPV, hrHPV, mixed HPV and total HPV in different age groups.

Figure 2. Prevalence of different HPV genotypes.

Table 2. The prevalence of all HPV genotypes in 21,862 tested women.

		≤25 y (n = 1489)		26-35 y (n = 6867)		36-45 y (n = 7162)		46-55 y (n = 4694)		>55 y (n = 1650)		All Ages (n = 21862)
	Genotype	Positive (n)	Positive (%)	Positive (n)	Positive (%)	Positive (n)	Positive (%)	Positive (n)	Positive (%)	Positive (n)	Positive (%)	Positive (n)	Positive (%)
hrHPV genotype	16	62	4.2	180	2.6	183	2.6	141	3.0	67	4.1	633	2.9
	18	26	1.7	47	0.7	52	0.7	44	0.9	19	1.2	188	0.9
	31	13	0.9	27	0.4	44	0.6	20	0.4	9	0.5	113	0.5
	33	10	0.7	33	0.5	45	0.6	45	1.0	17	1.0	150	0.7
	35	9	0.6	26	0.4	26	0.4	16	0.3	14	0.8	91	0.4
	39	9	0.6	41	0.6	48	0.7	34	0.7	7	0.4	139	0.6
	45	7	0.5	13	0.2	4	0.1	9	0.2	9	0.5	42	0.2
	51	30	2.0	92	1.3	90	1.3	58	1.2	22	1.3	292	1.3
	52	42	2.8	150	2.2	149	2.1	99	2.1	56	3.4	496	2.3
	53	33	2.2	92	1.3	105	1.5	110	2.3	54	3.3	394	1.8
	56	24	1.6	69	1.0	55	0.8	68	1.4	37	2.2	253	1.2
	58	32	2.1	83	1.2	106	1.5	68	1.4	30	1.8	319	1.5
	59	27	1.8	50	0.7	56	0.8	35	0.7	14	0.8	182	0.8
	66	21	1.4	49	0.7	50	0.7	44	0.9	13	0.8	177	0.8
	68	23	1.5	56	0.8	85	1.2	42	0.9	27	1.6	233	1.1
	73	4	0.3	6	0.1	8	0.1	10	0.2	4	0.2	32	0.1
	82	6	0.4	9	0.1	1	0.0	4	0.1	1	0.1	21	0.1
lrHPV genotype	6	37	2.5	48	0.7	38	0.5	29	0.6	19	1.2	171	0.8
	11	27	1.8	42	0.6	38	0.5	28	0.6	16	1.0	151	0.7
	42	17	1.1	57	0.8	59	0.8	51	1.1	25	1.5	209	1.0
	43	18	1.2	64	0.9	46	0.6	47	1.0	26	1.6	201	0.9
	81	27	1.8	58	0.8	93	1.3	86	1.8	35	2.1	299	1.4
	83	0	0.0	6	0.1	6	0.1	4	0.1	2	0.1	18	0.1

Figure 3. Proportion of infections with single, double, triple, quadruple and five or more genotypes.

Table 3. Age-stratified distribution of single and multiple genotypes of HPV infection.

Age Group, y	Single HPV genotype		Double HPV genotypes		Triple HPV genotypes		Quadruple HPV genotypes		≥Five HPV genotypes		Total No.
	No.	Proportion (%)	No.	Proportion (%)	No.	Proportion (%)	No.	Proportion (%)	No.	Proportion (%)
≤25^#	220	66.1	74	22.2	26	7.8	9	2.7	4	1.2	333
26–35	787	77.5	190	18.7	27	2.7	9	0.9	3	0.3	1016
36–45	858	78.8	176	16.2	43	3.9	8	0.7	4	0.4	1089
46–55	603	74.6	145	17.9	50	6.2	4	0.5	6	0.7	808
>55^##	224	64.9	84	24.3	23	6.7	8	2.3	6	1.7	345
Total	2692	75.0	669	18.6	169	4.7	38	1.1	23	0.6	3591

^#: The multi-infection rate in the ≤25 age group was significantly higher than that in the other age groups, P = 4.198e-6.

^##: The multi-infection rate in the >55 age group was significantly higher than that in the other age groups, P < 2.2e-16.

Table 4. Distribution of lrHPV-only, hrHPV-only, and mixed lrHPV and hrHPV infections in infections with different genotypes.

Number of co-infections	lrHPV-only		hrHPV-only		Mixed lrHPV and hrHPV		Total No.
	No.	Proportion (%)	No.	Proportion (%)	No.	Proportion (%)
Single HPV genotype	544	20.2	2148	79.8			2692
Double HPV genotypes	41	6.1	388	58.0	240	35.9	669
Triple HPV genotypes	1	0.6	77	45.6	91	53.8	169
Quadruple HPV genotypes	0	0	9	23.7	29	76.3	38
≥Five HPV genotypes	0	0	4	17.4	19	82.6	23
Total	586		2626		379		3591

Table 5. The prevalence of HPV in the year of 2019 and 2021.

	2019	2021
Hpv(+)	3053	3591
Total	13902	21862
HPV-positive (%)	22.00%	16.40%
P	<2.2e-16